Construction of a Biomimetic Tubular Scaffold Inspired by Sea Sponge Structure: Sponge‐Like Framework and Cell Guidance
Source abstract
Abstract
Abstract Engineering hollow fibers with precise surface microstructures is challenging; yet, essential for guiding cells alignment and ensuring proper vascular tissue function. Inspired by Euplectella sponges, a novel strategy to engineer biomimetic hollow fibers with spiral surface microstructures is developed. Using oxidized bacterial cellulose, bacterial cellulose, and polydopamine, a “brick‐and‐mortar” scaffold is created through precise shear control during microfluidic coaxial spinning. The scaffold mimics natural extracellular matrices, providing mechanical stability and supporting cell growth. In vitro studies show successful co‐culture of endothelial cells (ECs) and smooth muscle cells (SMCs), with SMCs aligning along spiral surface microstructures and ECs forming a confluent inner layer. In vivo implantation confirms biocompatibility, biodegradability, and low immunogenicity. This Euplectella‐inspired scaffold presents a promising approach for vascular tissue engineering and regenerative medicine.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Electrospun Nanofibers in Biomedical Applications · Bone Tissue Engineering Materials
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
College of Chemistry and Environmental Engineering Shenzhen University Shenzhen Guangdong 518000 China
Department of Biomedical Engineering School of Medicine Shenzhen University Shenzhen Guangdong 518000 China
Guangdong Provincial Key Laboratory of Micro/Nano Optomechatronics Engineering College of Mechatronics and Control Engineering Shenzhen University Shenzhen Guangdong 518000 China
Department of Urology Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen University Shenzhen Second People's Hospital Shenzhen Guangdong 518037 China
Funding
National Natural Science Foundation of China · Natural Science Foundation of Guangdong Province · Shenzhen Science and Technology Innovation Program · Basic and Applied Basic Research Foundation of Guangdong Province
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