journal article·2021-05Open access

Ferroptosis: A Combined Model of Human iPSC‐Derived Liver Organoids and Hepatocytes Reveals Ferroptosis in DGUOK Mutant mtDNA Depletion Syndrome (Adv. Sci. 10/2021)

Jingyi Guo, Lifan Duan, Xueying He, Shengbiao Li, Yi Wu, Ge Xiang, Feixiang Bao, Liang Yang, Hongyan Shi, Mi Gao, Lingjun Zheng, Huili Hu, Xingguo Liu

Advanced Science· Volume 8· Issue 10

Abstract

Cover story shows the amazing Chinese story of Monkey King named Sun Wukong got the Key Stand Iron Rod in East Sea as his weapon—Gold‐Banded Cudgel. In article number 2004680, Xingguo Liu and co‐workers demonstrate a sensitivity to iron overload‐induced ferroptosis in mitochondrial DNA depletion syndrome patients, which suggests potential protective effect of mitochondria in cell from ferroptosis. In the cover, iron (Gold‐Banded Cudgel) unbalance induces ferroptosis (East Sea turbulence), which could be protected by mitochondria (Monkey King with Heart Armor). [Image: see text]
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Research context

OpenAlex topics: Trace Elements in Health · Ferroptosis and cancer prognosis · RNA modifications and cancer

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