DataVXAdvanced SciencePaper
journal article·2025-05Open access

A Real‐Time Cell Death Self‐Reporting Theranostic Agent for Dynamic Optimization of Photodynamic Therapy

Wei Bian, Qiyue Wang, Cui He, Pan Tao, Juanjuan Zheng, Yulu Zhang, Jing Li, Fangyuan Li, Hongyan Jia, Daishun Ling

Advanced Science· Volume 12· Issue 17
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Source abstract

Abstract

Abstract The therapeutic efficiency of photodynamic therapy (PDT) hinges on the drug‐light interval (DLI), yet conventional approaches relying on photosensitizer accumulation often lead to suboptimal irradiation and adverse side effects. Here, a real‐time cell death self‐reporting photodynamic theranostic nanoagent (CDPN) is presented that dynamically monitors extracellular potassium ion ([K⁺] ex ) fluctuations as direct indicators of tumor cell death. By exploiting [K⁺] ex dyshomeostasis associated with apoptosis and necrosis, CDPN combines a photosensitizer and a potassium‐sensitive fluorophore within mesoporous silica nanoparticles, encapsulated by a K⁺‐selective membrane for enhanced specificity. In vitro and in vivo studies validate that [K⁺] ex dynamics closely correlate with cell death, enabling precise evaluation of PDT efficacy and data‐driven optimization of the DLI. Using a breast cancer model, CDPN‐guided adjustments identify optimized DLI conditions, achieving significantly improved therapeutic outcomes. This study introduces a new paradigm for PDT, establishing a real‐time, adaptable strategy for guiding treatment parameters and advancing precision oncology.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Photodynamic Therapy Research Studies · Photoacoustic and Ultrasonic Imaging

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Breast Surgery First Hospital of Shanxi Medical University Taiyuan 030001 China

Key Laboratory of Cellular Physiology at Shanxi Medical University Ministry of Education Taiyuan 030000 China

Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering School of Biomedical Engineering National Center for Translational Medicine Shanghai Jiao Tong University Shanghai 200240 China

Department of Clinical Laboratory Songjiang Research Institute Shanghai Key Laboratory of Emotions and Affective Disorders (LEAD) Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 201600 China

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Shanxi Province · Science and Technology Innovation Plan Of Shanghai Science and Technology Commission

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