journal article·2024-10Open access

Increased GluK1 Subunit Receptors in Corticostriatal Projection from the Anterior Cingulate Cortex Contributed to Seizure‐Like Activities

Xu‐Hui Li, Wantong Shi, Zhi‐Xia Zhao, Takanori Matsuura, Jing‐Shan Lu, Jingmin Che, Qi‐Yu Chen, Zhaoxiang Zhou, Man Xue, Shun Hao, Fang Xu, Guo‐Qiang Bi, Bong‐Kiun Kaang, Graham L. Collingridge, Min Zhuo

Advanced Science· Volume 11· Issue 39

Abstract

Abstract The corticostriatal connection plays a crucial role in cognitive, emotional, and motor control. However, the specific roles and synaptic transmissions of corticostriatal connection are less studied, especially the corticostriatal transmission from the anterior cingulate cortex (ACC). Here, a direct glutamatergic excitatory synaptic transmission in the corticostriatal projection from the ACC is found. Kainate receptors (KAR)‐mediated synaptic transmission is increased in this corticostriatal connection both in vitro and in vivo seizure‐like activities. GluK1 containing KARs and downstream calcium‐stimulated adenylyl cyclase subtype 1 (AC1) are involved in the upregulation of KARs following seizure‐like activities. Inhibiting the activities of ACC or its corticostriatal connection significantly attenuated pentylenetetrazole (PTZ)‐induced seizure. Additionally, injection of GluK1 receptor antagonist UBP310 or the AC1 inhibitor NB001 both show antiepileptic effects. The studies provide direct evidence that KARs are involved in seizure activity in the corticostriatal connection and the KAR‐AC1 signaling pathway is a potential novel antiepileptic strategy.
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Research context

OpenAlex topics: Neuroscience and Neuropharmacology Research · Ion channel regulation and function · Receptor Mechanisms and Signaling

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Center for Neuron and Disease Frontier Institute of Science and Technology Xi'an Jiaotong University Xi'an Shaanxi 710049 China

Department of Physiology Faculty of Medicine University of Toronto Medical Science Building, 1 King's College Circle Toronto Ontario M5S 1A8 Canada

Department of Orthopaedics School of Medicine University of Occupational and Environmental Health Yahatanishi‐ku Kitakyushu 807–8555 Japan

Shaanxi Provincial Key Laboratory of Infection and Immune Diseases Shaanxi Provincial People's Hospital Xi'an Shaanxi 710068 China

CAS Key Laboratory of Brain Connectome and Manipulation Interdisciplinary Center for Brain Information The Brain Cognition and Brain Disease Institute Shenzhen Institute of Advanced Technology Shenzhen Guangdong 518055 China

Department of Neurology First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510130 China

Department of Pharmacology Qingdao University School of Pharmacy Qingdao Shandong 266071 China

Department of Biological Sciences College of Natural Sciences Seoul National University Seoul 151–746 South Korea

Funding

National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities

References (68)

Show source-provided references
1. 10.1038/nrn348210.1038/nrn3482 ↗
2. Lenck‐Santini P. P. · 2022 · 65
3. Chen L. Y. · Signal Transduct. Tar. · 2023 · 8
4. 10.1016/j.neuron.2013.04.02710.1016/j.neuron.2013.04.027 ↗
5. 10.1038/nn126010.1038/nn1260 ↗
6. Zhao J. L. · Nat. Commun. · 2022 · 13
7. 10.2174/1570159X1866620083115465810.2174/1570159X18666200831154658 ↗
8. Chang W. P. · Front. Integrat. Neurosci. · 2014 · 7 · 104
9. 10.1016/j.coph.2014.11.01210.1016/j.coph.2014.11.012 ↗
10. Goldenberg M. M. · P&T · 2010 · 35 · 392
11. P.Ortinski K. J.Meador E&B2004 5 S60‐S65.10.1016/j.yebeh.2003.11.008 ↗
12. 10.1523/JNEUROSCI.1469-05.200510.1523/JNEUROSCI.1469-05.2005 ↗
13. 10.1016/j.neuron.2013.09.04510.1016/j.neuron.2013.09.045 ↗
14. 10.1002/ana.1053410.1002/ana.10534 ↗
15. 10.1016/j.neuron.2016.04.00110.1016/j.neuron.2016.04.001 ↗
16. 10.1093/cercor/bhs02210.1093/cercor/bhs022 ↗
17. 10.1016/j.celrep.2014.06.03210.1016/j.celrep.2014.06.032 ↗
18. 10.1038/nn88010.1038/nn880 ↗
19. 10.1038/sj.npp.130163310.1038/sj.npp.1301633 ↗
20. 10.1038/8843210.1038/88432 ↗
21. 10.1523/JNEUROSCI.5307-13.201410.1523/JNEUROSCI.5307-13.2014 ↗
22. Turek G. · E&B · 2022 · 126
23. 10.1186/1471-2202-15-310.1186/1471-2202-15-3 ↗
24. 10.1016/j.neuroscience.2015.03.04310.1016/j.neuroscience.2015.03.043 ↗
25. 10.1177/153575971882284310.1177/1535759718822843 ↗
26. 10.1523/JNEUROSCI.1788-17.201810.1523/JNEUROSCI.1788-17.2018 ↗
27. Vizcarra‐Chacón B. J. · BMC Neurosci. · 2013 · 14
28. 10.1186/s13041-017-0297-810.1186/s13041-017-0297-8 ↗
29. 10.1016/j.neuron.2014.12.02110.1016/j.neuron.2014.12.021 ↗
30. 10.1523/JNEUROSCI.2644-14.201510.1523/JNEUROSCI.2644-14.2015 ↗
31. 10.1016/j.celrep.2017.01.07310.1016/j.celrep.2017.01.073 ↗
32. 10.1016/j.yebeh.2019.10647410.1016/j.yebeh.2019.106474 ↗
33. Falcon‐Moya R. · Eur. J. Neurosci. · 2018 · 11 · 217
34. 10.1016/j.eplepsyres.2006.08.00810.1016/j.eplepsyres.2006.08.008 ↗
35. 10.1016/j.biopsych.2019.11.01410.1016/j.biopsych.2019.11.014 ↗
36. 10.1038/s41467-019-09954-910.1038/s41467-019-09954-9 ↗
37. 10.1111/j.1460-9568.2007.05316.x10.1111/j.1460-9568.2007.05316.x ↗
38. 10.3389/fnsys.2016.0010410.3389/fnsys.2016.00104 ↗
39. 10.1016/j.neuron.2014.07.03310.1016/j.neuron.2014.07.033 ↗
40. 10.1111/ejn.1259010.1111/ejn.12590 ↗
41. 10.1523/JNEUROSCI.20-06-02175.200010.1523/JNEUROSCI.20-06-02175.2000 ↗
42. 10.1016/j.neuropharm.2008.08.02310.1016/j.neuropharm.2008.08.023 ↗
43. 10.1186/s13041-017-0336-510.1186/s13041-017-0336-5 ↗
44. 10.1152/jn.00091.200510.1152/jn.00091.2005 ↗
45. Shangguan Y. · Cerebral Cortex · 2017 · 1
46. 10.1126/science.116520910.1126/science.1165209 ↗
47. 10.1038/nature2167810.1038/nature21678 ↗
48. 10.1016/j.neuron.2014.06.03010.1016/j.neuron.2014.06.030 ↗
49. Chen T. · Mol. Pain · 2014 · 10 · 65
50. 10.1016/j.drudis.2012.01.00910.1016/j.drudis.2012.01.009 ↗
51. 10.1002/cne.2103910.1002/cne.21039 ↗
52. 10.1152/jn.00453.201210.1152/jn.00453.2012 ↗
53. 10.2174/13816120778076586410.2174/138161207780765864 ↗
54. 10.1038/s42003-023-05589-110.1038/s42003-023-05589-1 ↗
55. 10.1186/s13041-014-0076-810.1186/s13041-014-0076-8 ↗
56. 10.1038/s41586-022-05483-610.1038/s41586-022-05483-6 ↗
57. 10.1097/NEN.0b013e3182a4b26610.1097/NEN.0b013e3182a4b266 ↗
58. 10.1124/jpet.109.15390810.1124/jpet.109.153908 ↗
59. 10.1016/j.neuropharm.2004.02.01010.1016/j.neuropharm.2004.02.010 ↗
60. Liu S.b. · J. Neurochem. · 2019
61. 10.1016/j.jpain.2022.03.06910.1016/j.jpain.2022.03.069 ↗
62. 10.1177/1744806922108703410.1177/17448069221087034 ↗
63. 10.1038/s41587-021-00986-510.1038/s41587-021-00986-5 ↗
64. 10.1016/j.celrep.2021.10941110.1016/j.celrep.2021.109411 ↗
65. 10.1523/JNEUROSCI.3195-17.201810.1523/JNEUROSCI.3195-17.2018 ↗
66. 10.1523/JNEUROSCI.0925-17.201710.1523/JNEUROSCI.0925-17.2017 ↗
67. 10.1523/JNEUROSCI.19-16-06733.199910.1523/JNEUROSCI.19-16-06733.1999 ↗
68. 10.1177/174480691771984710.1177/1744806917719847 ↗