Allosteric Activation of Transglutaminase 2 via Inducing an “Open” Conformation for Osteoblast Differentiation (Adv. Sci. 18/2023)

Allosteric Activation of Transglutaminase 2 Transglutaminase 2 (TGM2) serves as a cellular target of small molecule forskolin to promote osteoblast differentiation and ameliorate ovariectomy-induced osteoporosis. Forskolin binds to TGM2 on a previously undisclosed allosteric site to activate TGM2 by inducing an “open” conformation, thereby improving mitochondrial energy metabolism for osteoporosis treatment. More details can be found in article number 2206533 by Ke-Wu Zeng and co-workers.