Reprogramming of Mitochondrial Respiratory Chain Complex by Targeting SIRT3‐COX4I2 Axis Attenuates Osteoarthritis Progression (Adv. Sci. 10/2023)

Mitochondrial Reprogramming in Osteoarthritis The Mengtian and Wentian lab modules docked with Tianhe core module after entering the planned orbit. The successful docking boosts the construction of Tiangong space station project. In article number 2206144, Huilin Yang, Fan He, Xuesong Zhu, and co-workers uncovered that SIRT3 reprograms the mitochondrial respiratory chain complex via targeted deacetylation of COX4I2 to protect against osteoarthritis progression. Just like the satellite docking for exploring cosmic mysteries, the activation of SIRT3-COX4I2 axis in mitochondria sheds new light on the pathogenesis of osteoarthritis.