High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection
Source abstract
Abstract
Abstract Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system (CNS) believed to be driven by autoimmune mechanisms. Genetic and environmental factors are implicated in MS development, and among the latter, diets and nutrients are emerging as potential critical contributors. However, a comprehensive understanding of their impacts and the underlying mechanisms involved is lacking. Harnessing state‐of‐the‐art nutritional geometry analytical methods, it is first revealed that globally, increased carbohydrate supply is associated with increased MS disease burden, while fat supply has an opposite effect. Furthermore, in a MS mouse model, experimental autoimmune encephalomyelitis (EAE), it is found that an isocaloric diet high in carbohydrate aggravated EAE, while a diet enriched in fat (HF) is fully protective. This is reflected by reduced neuroinflammation and skewing toward anti‐inflammatory phenotypes. The protective effects from the HF diet are multifaceted. Metabolically, HF increased lipid storage in immune cells, correlating with their increased anti‐inflammatory IL‐10 production. Transcriptionally and epigenetically, HF feeding preprogrammed naïve T cells toward a less activated but more tolerogenic phenotype. It is showcased that manipulating diets is a potentially efficient and cost‐effective approach to prevent and/or ameliorate EAE. This exhibits translational potentials for prevention/intervention of MS and possibly other autoimmune diseases.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Immune Cell Function and Interaction · Cytokine Signaling Pathways and Interactions · Immune cells in cancer
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Charles Perkins Centre The University of Sydney D17 Charles Perkins Centre Sydney NSW 2006 Australia
School of Medical Sciences Faculty of Medicine and Health The University of Sydney Sydney NSW 2006 Australia
Sydney Medical School Nepean The University of Sydney Sydney NSW 2747 Australia
Nepean Hospital Nepean Blue Mountains Local Health District Sydney NSW 2747 Australia
School of Life and Environmental Sciences The University of Sydney Sydney NSW 2006 Australia
Sydney Precision Data Science Centre The University of Sydney Sydney NSW 2006 Australia
Viral immunopathology Laboratory Infection Immunity and Inflammation Research Theme School of Medical Sciences Faculty of Medicine and Health The University of Sydney Sydney NSW 2006 Australia
Brain and Mind Centre The University of Sydney Sydney NSW 2006 Australia
The University of Sydney Institute for Infectious Diseases The University of Sydney Sydney NSW 2006 Australia
Sydney Nano The University of Sydney Sydney NSW 2006 Australia
Novo Nordisk Foundation Center for Basic Metabolic Research University of Copenhagen Copenhagen 2200 Denmark
Institut de Pharmacologie Moléculaire et Cellulaire Université Côte d'Azur & Centre National pour la Recherche Scientifique (CNRS) Valbonne 06560 France
Funding
Novo Nordisk Foundation Center for Basic Metabolic Research · Australian Research Council
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