journal article·2025-05Open access

Enhancing Osteogenesis through Bio‐Inspired Recombinant Coral Protein Galaxin by Targeting Mitochondrial Metabolism and ATP Production

Fei Yu, Xing Zhao, Ting Jiang, Ningjuan Ouyang, Peilin Li, Wei Yang, Zhihe Zhao

Advanced Science· Volume 12· Issue 17

Abstract

Abstract Bio‐inspired coral‐derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, the role of the recombinant coral protein galaxin in promoting osteogenesis is investigated. The observations reveal that recombinant galaxin regulates the mitochondrial metabolism in mouse pre‐osteoblasts by interacting with the β subunit of ATP synthase. This ultimately promotes osteogenesis of pre‐osteoblasts. Furthermore, galaxin is integrated with gelatin methacryloyl (GelMA) and assess the osteogenic potential of the resulting galaxin‐GelMA composites in mouse mandibular defects. The observations emphasize the distinctive role of galaxin in regulating mitochondrial functionality and osteogenesis. Additionally, these provide prospective insights for further applications of bio‐inspired recombinant coral proteins in regenerative medicine.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Connective tissue disorders research · RNA Interference and Gene Delivery · Aquaculture disease management and microbiota

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Oral Diseases National Center for Stomatology National Clinical Research Center for Oral Diseases Department of Orthodontics West China Hospital of Stomatology Sichuan University Chengdu 610041 China

Department of Nephrology Kidney Research Institute West China Hospital of Sichuan University Chengdu 610041 China

Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 610031 China

Department of Pediatric Dentistry Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai 200011 China

Department of Orthodontics Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai 200011 China

College of Polymer Science and Engineering Med‐X Center for Materials Sichuan University Chengdu 610065 China

Funding

National Natural Science Foundation of China · Natural Science Foundation of Sichuan Province · China Postdoctoral Science Foundation

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