journal article·2025-03Open access

Precise Sizing and Collision Detection of Functional Nanoparticles by Deep Learning Empowered Plasmonic Microscopy

Jingan Wang, Yi Sun, Yuting Yang, Cheng Zhang, Weiqiang Zheng, Chen Wang, Wei Zhang, Lianqun Zhou, Hui Yu, Jinghong Li

Advanced Science· Volume 12· Issue 9

Abstract

Abstract Single nanoparticle analysis is crucial for various applications in biology, materials, and energy. However, precisely profiling and monitoring weakly scattering nanoparticles remains challenging. Here, it is demonstrated that deep learning‐empowered plasmonic microscopy (Deep‐SM) enables precise sizing and collision detection of functional chemical and biological nanoparticles. Image sequences are recorded by the state‐of‐the‐art plasmonic microscopy during single nanoparticle collision onto the sensor surface. Deep‐SM can enhance signal detection and suppresses noise by leveraging spatio‐temporal correlations of the unique signal and noise characteristics in plasmonic microscopy image sequences. Deep‐SM can provide significant scattering signal enhancement and noise reduction in dynamic imaging of biological nanoparticles as small as 10 nm, as well as the collision detection of metallic nanoparticle electrochemistry and quantum coupling with plasmonic microscopy. The high sensitivity and simplicity make this approach promising for routine use in nanoparticle analysis across diverse scientific fields.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Advanced biosensing and bioanalysis techniques · Plasmonic and Surface Plasmon Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

School of Biomedical Engineering Shanghai Jiao Tong University Shanghai 200030 China

Department of Chemistry Center for BioAnalytical Chemistry Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology Tsinghua University Beijing 100084 China

Chinese Academy of Sciences Key Laboratory of Urban Pollutant Conversion Department of Environmental Science and Engineering University of Science and Technology of China Hefei 230026 China

School of Sensing Science and Engineering School of Electronic Information and Electrical Engineering Shanghai Jiao Tong University Shanghai 200030 China

Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · China Postdoctoral Science Foundation

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