journal article·2025-05Open access

Single Test‐Based Diagnosis and Subtyping of Pulmonary Hypertension Caused by Fibrosing Mediastinitis Using Plasma Metabolic Analysis

Yating Zhao, Chunmeng Ding, Hongling Su, Aqian Wang, Aiping Tang, Hongfan Zhao, Ya Ma, Min Zhang, Wanshan Liu, Ruimin Wang, Ziyue Zhang, Shouzhi Yang, Dingyitai Liang, Yida Huang, Kun Qian, Lin Huang, Qihua Fu, Yunshan Cao

Advanced Science· Volume 12· Issue 17

Abstract

Abstract Pulmonary hypertension (PH) often leads to poor survival outcomes and encompasses diverse subtypes with distinct underlying causes. Specifically, PH resulting from fibrosing mediastinitis (FM‐PH) presents significant diagnostic challenges due to nonspecific symptoms and overlap of clinical characterization with other PH subtypes, leading to frequent misdiagnosis and delayed treatment. Moreover, the complex diagnostic procedures impose a significant burden on FM‐PH patients, many of whom already experience mobility difficulties. This study represents a single test‐based diagnosis of FM‐PH, using the plasma metabolites obtained through ferric particle‐enhanced laser desorption/ionization mass spectrometry analysis. Distinct metabolic alterations in FM‐PH are identified compared to healthy controls and other PH subtypes, achieving an area under the curve (AUC) of 0.987 for FM‐PH diagnosis and 0.728 for differentiating FM‐PH from other subtypes. By addressing existing gaps in diagnostic strategies, this research highlights the potential of metabolic analysis in elucidating the metabolic landscape of PH.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis · Pulmonary Hypertension Research and Treatments · Medical Imaging and Pathology Studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Heart, Lung and Vessels Center Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 China

School of Medicine Jiangsu University Zhenjiang 212000 China

Department of Cardiology Pulmonary Vascular Disease Center (PVDC) Gansu Provincial Hospital Lanzhou 730000 China

State Key Laboratory of Systems Medicine for Cancer School of Biomedical Engineering Institute of Medical Robotics and Shanghai Academy of Experimental Medicine Shanghai Jiao Tong University Shanghai 200030 China

The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital) Lanzhou 730000 China

The First Clinical Medical School Lanzhou University Lanzhou 730000 China

Clinical Research Center Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 China

Department of Clinical Laboratory Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University Institute of Thoracic Oncology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200030 China

Center for Medical Genetics and Rare Diseases Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 China

Funding

National Natural Science Foundation of China · Science and Technology Program of Gansu Province · State Key Laboratory of Respiratory Disease

References (37)

Show source-provided references
1. 10.1038/s41572-023-00486-710.1038/s41572-023-00486-7 ↗
2. Ratwatte S. · Int. J. Cardiol. · 2024 · 17
3. 10.1016/j.jacasi.2021.11.01610.1016/j.jacasi.2021.11.016 ↗
4. 10.1097/MD.000000000000180010.1097/MD.0000000000001800 ↗
5. 10.1183/13993003.01904-201810.1183/13993003.01904-2018 ↗
6. 10.1038/s44321-024-00033-110.1038/s44321-024-00033-1 ↗
7. 10.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b610.1371/annotation/c7bddd8d-9f15-45f4-a886-740b351a39b6 ↗
8. 10.1371/journal.pone.009533110.1371/journal.pone.0095331 ↗
9. 10.1161/CIRCULATIONAHA.116.02460210.1161/CIRCULATIONAHA.116.024602 ↗
10. 10.1038/s41598-022-17374-x10.1038/s41598-022-17374-x ↗
11. 10.7326/AITC20210420010.7326/AITC202104200 ↗
12. 10.1161/CIRCRESAHA.117.31131210.1161/CIRCRESAHA.117.311312 ↗
13. 10.1183/16000617.0104-201610.1183/16000617.0104-2016 ↗
14. 10.1146/annurev-physiol-031620-12395610.1146/annurev-physiol-031620-123956 ↗
15. 10.1002/advs.20240623310.1002/advs.202406233 ↗
16. 10.1161/CIRCULATIONAHA.118.03588910.1161/CIRCULATIONAHA.118.035889 ↗
17. 10.1183/13993003.00332-202010.1183/13993003.00332-2020 ↗
18. 10.1093/eurheartj/ehad04410.1093/eurheartj/ehad044 ↗
19. 10.1161/CIRCULATIONAHA.116.02455710.1161/CIRCULATIONAHA.116.024557 ↗
20. 10.1016/j.healun.2024.02.00410.1016/j.healun.2024.02.004 ↗
21. 10.1161/CIRCULATIONAHA.111.06292710.1161/CIRCULATIONAHA.111.062927 ↗
22. 10.1093/ajh/hpz12110.1093/ajh/hpz121 ↗
23. 10.1002/VIW.2022004010.1002/VIW.20220040 ↗
24. 10.1002/VIW.2024003110.1002/VIW.20240031 ↗
25. 10.1097/HEP.000000000000095710.1097/HEP.0000000000000957 ↗
26. 10.1016/j.cmet.2023.11.01310.1016/j.cmet.2023.11.013 ↗
27. 10.1161/CIRCULATIONAHA.123.06757910.1161/CIRCULATIONAHA.123.067579 ↗
28. 10.1016/j.redox.2023.10279710.1016/j.redox.2023.102797 ↗
29. 10.1161/CIRCRESAHA.120.31678410.1161/CIRCRESAHA.120.316784 ↗
30. 10.1016/j.celrep.2019.11.03710.1016/j.celrep.2019.11.037 ↗
31. 10.1161/CIRCULATIONAHA.118.03458810.1161/CIRCULATIONAHA.118.034588 ↗
32. 10.1183/13993003.01700-201910.1183/13993003.01700-2019 ↗
33. 10.1002/VIW.2020011810.1002/VIW.20200118 ↗
34. 10.1021/acsnano.3c0376510.1021/acsnano.3c03765 ↗
35. 10.1038/s41893-024-01323-910.1038/s41893-024-01323-9 ↗
36. 10.1136/gutjnl-2023-33004510.1136/gutjnl-2023-330045 ↗
37. 10.1073/pnas.212224511910.1073/pnas.2122245119 ↗