Remediation of Metal Oxide Nanotoxicity with a Functional Amyloid
Source abstract
Abstract
Abstract Understanding the environmental health and safety of nanomaterials (NanoEHS) is essential for the sustained development of nanotechnology. Although extensive research over the past two decades has elucidated the phenomena, mechanisms, and implications of nanomaterials in cellular and organismal models, the active remediation of the adverse biological and environmental effects of nanomaterials remains largely unexplored. Inspired by recent developments in functional amyloids for biomedical and environmental engineering, this work shows their new utility as metallothionein mimics in the strategically important area of NanoEHS. Specifically, metal ions released from CuO and ZnO nanoparticles are sequestered through cysteine coordination and electrostatic interactions with beta‐lactoglobulin (bLg) amyloid, as revealed by inductively coupled plasma mass spectrometry and molecular dynamics simulations. The toxicity of the metal oxide nanoparticles is subsequently mitigated by functional amyloids, as validated by cell viability and apoptosis assays in vitro and murine survival and biomarker assays in vivo. As bLg amyloid fibrils can be readily produced from whey in large quantities at a low cost, the study offers a crucial strategy for remediating the biological and environmental footprints of transition metal oxide nanomaterials.
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Research context
OpenAlex topics: Nanoparticles: synthesis and applications · Heavy Metal Exposure and Toxicity · Trace Elements in Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Biomedical Sciences and Engineering Guangzhou International Campus South China University of Technology Guangzhou 510006 China
Nanomedicine Center Great Bay Area National Institute for Nanotechnology Innovation 136 Kaiyuan Avenue Guangzhou 510700 China
Drug Delivery Disposition and Dynamics Monash Institute of Pharmaceutical Sciences Monash University 381 Royal Parade Parkville VIC 3052 Australia
Department of Engineering Mechanics Hohai University Nanjing 211100 China
Department of Physics and Astronomy Clemson University Clemson SC 29634 USA
College of Environmental Science and Engineering Key Laboratory of Yangtze River Water Environment Tongji University 1239 Siping Road Shanghai 200092 China
Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Fudan University Shanghai 200032 China
Laboratory of Environmental Toxicology National Institute of Chemical Physics and Biophysics Akadeemia tee 23 Tallinn 12618 Estonia
Funding
National Natural Science Foundation of China · Eesti Teadusagentuur · Fundamental Research Funds for the Central Universities · Key Technologies Research and Development Program
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