journal article·2024-11Open access

Tumor‐Resident Microbiota‐Based Risk Model Predicts Neoadjuvant Therapy Response of Locally Advanced Esophageal Squamous Cell Carcinoma Patients

Hong Wu, Qianshi Liu, Jingpei Li, Xuefeng Leng, Yazhou He, Yiqiang Liu, Xia Zhang, Yujie Ouyang, Yang Liu, Wenhua Liang, Chuan Xu

Advanced Science· Volume 11· Issue 41

Abstract

Abstract Few predictive biomarkers exist for identifying patients who may benefit from neoadjuvant therapy (NAT). The intratumoral microbial composition is comprehensively profiled to predict the efficacy and prognosis of patients with esophageal squamous cell carcinoma (ESCC) who underwent NAT and curative esophagectomy. Least Absolute Shrinkage and Selection Operator (LASSO) regression analysis is conducted to screen for the most closely related microbiota and develop a microbiota‐based risk prediction (MRP) model on the genera of TM7x, Sphingobacterium, and Prevotella. The predictive accuracy and prognostic value of the MRP model across multiple centers are validated. The MRP model demonstrates good predictive accuracy for therapeutic responses in the training, validation, and independent validation sets. The MRP model also predicts disease‐free survival (p = 0.00074 in the internal validation set and p = 0.0017 in the independent validation set) and overall survival (p = 0.00023 in the internal validation set and p = 0.11 in the independent validation set) of patients. The MRP‐plus model basing on MRP, tumor stage, and tumor size can also predict the patients who can benefit from NAT. In conclusion, the developed MRP and MRP‐plus models may function as promising biomarkers and prognostic indicators accessible at the time of diagnosis.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Esophageal Cancer Research and Treatment · Pancreatic and Hepatic Oncology Research · Gastric Cancer Management and Outcomes

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Oncology & Cancer Institute Sichuan Academy of Medical Sciences Sichuan Provincial People's Hospital University of Electronic Science and Technology of China Chengdu Sichuan 610072 P. R. China

Sichuan Cancer Hospital & Institute Sichuan Cancer Center School of Medicine University of Electronic Science and Technology of China Chengdu Sichuan 610041 P. R. China

Jinfeng Laboratory Chongqing 400039 P. R. China

Yu‐Yue Pathology Scientific Research Center Chongqing 400039 P. R. China

Thoracic Surgery Department The First Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong 510230 P. R. China

Department of Oncology West China School of Public Health and West China Fourth Hospital Sichuan University Chengdu Sichuan 610041 P. R. China

Institute of Pathology and Southwest Cancer Center Ministry of Education of China Southwest Hospital Third Military Medical University (Army Medical University) and Key Laboratory of Tumor Immunopathology Chongqing 400038 P. R. China

Acupuncture and Massage College Chengdu University of Traditional Chinese Medicine Chengdu Sichuan 610072 P. R. China

Funding

National Key Research and Development Program of China Stem Cell and Translational Research · National Natural Science Foundation of China

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