Deconstruction of Vermal Cerebellum in Ramp Locomotion in Mice
Source abstract
Abstract
Abstract The cerebellum is involved in encoding balance, posture, speed, and gravity during locomotion. However, most studies are carried out on flat surfaces, and little is known about cerebellar activity during free ambulation on slopes. Here, it has been imaged the neuronal activity of cerebellar molecular interneurons (MLIs) and Purkinje cells (PCs) using a miniaturized microscope while a mouse is walking on a slope. It has been found that the neuronal activity of vermal MLIs specifically enhanced during uphill and downhill locomotion. In addition, a subset of MLIs is activated during entire uphill or downhill positions on the slope and is modulated by the slope inclines. In contrast, PCs showed counter‐balanced neuronal activity to MLIs, which reduced activity at the ramp peak. So, PCs may represent the ramp environment at the population level. In addition, chemogenetic inactivation of lobule V of the vermis impaired uphill locomotion. These results revealed a novel micro‐circuit in the vermal cerebellum that regulates ambulatory behavior in 3D terrains.
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Research context
OpenAlex topics: Neuroscience of respiration and sleep · Vestibular and auditory disorders · Mitochondrial Function and Pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Neurology of the Second Affiliated Hospital and Interdisciplinary Institute of Neuroscience and Technology Zhejiang University School of Medicine Hangzhou 310027 China
Department of Physiology and Department of Psychiatry Sir Run Run Shaw Hospital Zhejiang University School of Medicine Hangzhou 310058 China
Key Laboratory for Biomedical Engineering of Ministry of Education College of Biomedical Engineering and Instrument Science, Zhejiang University Hangzhou 310027 China
Department of Neuroscience City University of Hong Kong Kowloon Hong Kong China
MOE Frontier Science Center for Brain Science and Brain‐machine Integration School of Brain Science and Brain Medicine Zhejiang University Hangzhou 310027 China
Key Laboratory of Medical Neurobiology of Zhejiang Province Hangzhou 310027 China
Funding
National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities
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