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journal article·2023-08Open access

Mesenchymal Migration on Adhesive–Nonadhesive Alternate Surfaces in Macrophages

Fulin Xing, Hao Dong, Jianyu Yang, Chunhui Fan, Mengdi Hou, Ping Zhang, Fen Hu, Jun Zhou, Liangyi Chen, Leiting Pan, Jingjun Xu

Advanced Science· Volume 10· Issue 23
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Source abstract

Abstract

Abstract Mesenchymal migration usually happens on adhesive substrates, while cells adopt amoeboid migration on low/nonadhesive surfaces. Protein‐repelling reagents, e.g., poly(ethylene) glycol (PEG), are routinely employed to resist cell adhering and migrating. Contrary to these perceptions, this work discovers a unique locomotion of macrophages on adhesive–nonadhesive alternate substrates in vitro that they can overcome nonadhesive PEG gaps to reach adhesive regions in the mesenchymal mode. Adhering to extracellular matrix regions is a prerequisite for macrophages to perform further locomotion on the PEG regions. Podosomes are found highly enriched on the PEG region in macrophages and support their migration across the nonadhesive regions. Increasing podosome density through myosin IIA inhibition facilitates cell motility on adhesive–nonadhesive alternate substrates. Moreover, a developed cellular Potts model reproduces this mesenchymal migration. These findings together uncover a new migratory behavior on adhesive–nonadhesive alternate substrates in macrophages.
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Research context

OpenAlex topics: Cellular Mechanics and Interactions · Micro and Nano Robotics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

The Key Laboratory of Weak‐Light Nonlinear Photonics of Education Ministry School of Physics and TEDA Institute of Applied Physics Nankai University Tianjin 300071 China

State Key Laboratory of Medicinal Chemical Biology Frontiers Science Center for Cell Responses, College of Life Sciences Nankai University Tianjin 300071 China

State Key Laboratory of Membrane Biology, Institute of Molecular Medicine National Biomedical Imaging Center, Center for Life Sciences School of Future Technology Peking University Beijing 100871 China

Shenzhen Research Institute of Nankai University Shenzhen Guangdong 518083 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · China Postdoctoral Science Foundation · Higher Education Discipline Innovation Project · Fundamental Research Funds for the Central Universities

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