DataVXAdvanced SciencePaper
journal article·2023-06Open access

Antiviral Nanobiologic Therapy Remodulates Innate Immune Responses to Highly Pathogenic Coronavirus

Xuan Liu, Lunzhi Yuan, Jijing Chen, Yali Zhang, Peiwen Chen, Ming Zhou, Jiaxuan Xie, Jian Ma, Jianzhong Zhang, Kun Wu, Qiyi Tang, Quan Yuan, Huachen Zhu, Tong Cheng, Yi Guan, Gang Liu, Ningshao Xia

Advanced Science· Volume 10· Issue 17
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Abstract

Abstract Highly pathogenic coronavirus (CoV) infection induces a defective innate antiviral immune response coupled with the dysregulated release of proinflammatory cytokines and finally results in acute respiratory distress syndrome (ARDS). A timely and appropriate triggering of innate antiviral response is crucial to inhibit viral replication and prevent ARDS. However, current medical countermeasures can rarely meet this urgent demand. Here, an antiviral nanobiologic named CoVR‐MV is developed, which is polymerized of CoVs receptors based on a biomimetic membrane vesicle system. The designed CoVR‐MV interferes with the viral infection by absorbing the viruses with maximized viral spike target interface, and mediates the clearance of the virus through its inherent interaction with macrophages. Furthermore, CoVR‐MV coupled with the virus promotes a swift production and signaling of endogenous type I interferon via deregulating 7‐dehydrocholesterol reductase (DHCR7) inhibition of interferon regulatory factor 3 (IRF3) activation in macrophages. These sequential processes re‐modulate the innate immune responses to the virus, trigger spontaneous innate antiviral defenses, and rescue infected Syrian hamsters from ARDS caused by SARS‐CoV‐2 and all tested variants.
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Research context

PolymersNanomaterials

OpenAlex topics: SARS-CoV-2 and COVID-19 Research · COVID-19 Clinical Research Studies · Long-Term Effects of COVID-19

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Institute of Diagnostics and Vaccine Development in Infectious Diseases Center for Molecular Imaging and Translational Medicine School of Public Health & School of Life Sciences Xiamen University Xiamen 361102 China

State Key Laboratory of Emerging Infectious Diseases School of Public Health Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR 999077 China

Guangdong‐Hong Kong Joint Laboratory of Emerging Infectious Diseases Joint Laboratory for International Collaboration in Virology and Emerging Infectious Diseases Joint Institute of Virology (STU/HKU) Shantou University Shantou 515063 China

Department of Microbiology Howard University College of Medicine Washington DC 20059 USA

Funding

Major State Basic Research Development Program of China · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Guangdong Province · Program for New Century Excellent Talents in University

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