DataVXAdvanced SciencePaper
journal article·2022-12Open access

Small Molecular Inhibitors Reverse Cancer Metastasis by Blockading Oncogenic PITPNM3

Zihao Liu, Yu Shi, Li Lv, Jianing Chen, WenG. Jiang, Jun Li, Qun Lin, Xiaolin Fang, Jingbo Gao, Yujie Liu, Qiang Liu, Xiaoding Xu, Erwei Song, Chang Gong

Advanced Science· Volume 9· Issue 35
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Source abstract

Abstract

Abstract Most cancer‐related deaths are a result of metastasis. The development of small molecular inhibitors reversing cancer metastasis represents a promising therapeutic opportunity for cancer patients. This pan‐cancer analysis identifies oncogenic roles of membrane‐associated phosphatidylinositol transfer protein 3 (PITPNM3), which is crucial for cancer metastasis. Small molecules targeting PITPNM3 must be explored further. Here, PITPNM3‐selective small molecular inhibitors are reported. These compounds exhibit target‐specific inhibition of PITPNM3 signaling, thereby reducing metastasis of breast cancer cells. Besides, by using nanoparticle‐based delivery systems, these PITPNM3‐selective compounds loaded nanoparticles significantly repress metastasis of breast cancer in mouse xenograft models and organoid models. Notably, the results establish an important metastatic‐promoting role for PITPNM3 and offer PITPNM3 inhibition as a therapeutic strategy in metastatic breast cancer.
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Research context

Nanomaterials

OpenAlex topics: Protein Degradation and Inhibitors · Cancer Mechanisms and Therapy · Microtubule and mitosis dynamics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Breast Tumor Center Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou 510120 P. R. China

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou 510120 P. R. China

Department of Breast and Thyroid Surgery Shenzhen People's Hospital The Second Clinical Medical College of Jinan University The First Affiliated Hospital of Southern University of Science and Technology Shenzhen 518020 P. R. China

Department of Pharmacy Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 P. R. China

Cardiff China Medical Research Collaborative School of Medicine Cardiff University Heath Park Cardiff CF14 4XN UK

Department of Biochemistry Zhongshan School of Medicine Sun Yat‐sen University Guangzhou 510080 P. R. China

Funding

National Natural Science Foundation of China · Guangdong Science and Technology Department

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