journal article·2023-01Open access

Multiplexed Complementary Signal Transmission for a Self‐Regulating Artificial Nervous System

Young Jin Choi, Dong Gue Roe, Yoon Young Choi, Seongchan Kim, Sae Byeok Jo, Hwa Sung Lee, Do Hwan Kim, Jeong Ho Cho

Advanced Science· Volume 10· Issue 3

Abstract

Abstract Neuromorphic engineering has emerged as a promising research field that can enable efficient and sophisticated signal transmission by mimicking the biological nervous system. This paper presents an artificial nervous system capable of facile self‐regulation via multiplexed complementary signals. Based on the tunable nature of the Schottky barrier of a complementary signal integration circuit, a pair of complementary signals is successfully integrated to realize efficient signal transmission. As a proof of concept, a feedback‐based blood glucose level control system is constructed by incorporating a glucose/insulin sensor, a complementary signal integration circuit, an artificial synapse, and an artificial neuron circuit. Certain amounts of glucose and insulin in the initial state are detected by each sensor and reflected as positive and negative amplitudes of the multiplexed presynaptic pulses, respectively. Subsequently, the pulses are converted to postsynaptic current, which triggered the injection of glucose or insulin in a way that confined the glucose level to a desirable range. The proposed artificial nervous system demonstrates the notable potential of practical advances in complementary control engineering.
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Research context

OpenAlex topics: Advanced Memory and Neural Computing · Photoreceptor and optogenetics research · Neuroscience and Neural Engineering

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biomolecular Engineering Yonsei University Seoul 03722 Republic of Korea

School of Electrical and Electronic Engineering Yonsei University Seoul 03722 Republic of Korea

Department of Mechanical Science and Engineering University of Illinois at Urbana−Champaign Urbana IL 61801 USA

SKKU Advanced Institute of Nanotechnology (SAINT) Sungkyunkwan University Suwon 16419 Republic of Korea

School of Chemical Engineering SKKU Institute of Energy Science and Technology (SIEST) Sungkyunkwan University (SKKU) Suwon 16419 Republic of Korea

Department of Materials Science and Chemical Engineering Hanyang University Ansan 15588 Republic of Korea

Department of Chemical Engineering Hanyang University Seoul 04763 Republic of Korea

References (43)

Show source-provided references
1. 10.1002/j.2040-4603.2014.tb00574.x10.1002/j.2040-4603.2014.tb00574.x ↗
2. 10.1016/0166-2236(92)90092-M10.1016/0166-2236(92)90092-M ↗
3. 10.1161/01.RES.29.5.43710.1161/01.RES.29.5.437 ↗
4. 10.1016/j.pcd.2014.03.00110.1016/j.pcd.2014.03.001 ↗
5. 10.1111/jphp.1260710.1111/jphp.12607 ↗
6. 10.2165/00128071-200304100-0000110.2165/00128071-200304100-00001 ↗
7. 10.1038/s41563-019-0292-910.1038/s41563-019-0292-9 ↗
8. 10.1038/s41467-021-21890-110.1038/s41467-021-21890-1 ↗
9. 10.1038/s41467-020-16766-910.1038/s41467-020-16766-9 ↗
10. 10.1002/adma.20200265310.1002/adma.202002653 ↗
11. 10.1021/acsami.9b1774210.1021/acsami.9b17742 ↗
12. 10.1016/j.nanoen.2019.10409510.1016/j.nanoen.2019.104095 ↗
13. 10.1002/adma.20180288310.1002/adma.201802883 ↗
14. 10.1038/s41467-018-07572-510.1038/s41467-018-07572-5 ↗
15. 10.1002/adfm.20180439710.1002/adfm.201804397 ↗
16. 10.1021/acsami.6b0886610.1021/acsami.6b08866 ↗
17. 10.1038/ncomms415810.1038/ncomms4158 ↗
18. 10.1002/adma.20120311610.1002/adma.201203116 ↗
19. 10.1126/sciadv.abn183810.1126/sciadv.abn1838 ↗
20. 10.1126/science.abj794310.1126/science.abj7943 ↗
21. 10.1038/s41467-021-21319-910.1038/s41467-021-21319-9 ↗
22. 10.1126/sciadv.abe399610.1126/sciadv.abe3996 ↗
23. 10.1038/s41467-021-22680-510.1038/s41467-021-22680-5 ↗
24. 10.1002/adma.20200778210.1002/adma.202007782 ↗
25. 10.1002/adma.20210011910.1002/adma.202100119 ↗
26. 10.1038/s41467-020-16606-w10.1038/s41467-020-16606-w ↗
27. 10.1038/s41467-020-15759-y10.1038/s41467-020-15759-y ↗
28. 10.1038/s41467-020-17850-w10.1038/s41467-020-17850-w ↗
29. 10.1038/s41467-020-15378-710.1038/s41467-020-15378-7 ↗
30. 10.1002/advs.20190061710.1002/advs.201900617 ↗
31. 10.1038/s41467-019-13177-310.1038/s41467-019-13177-3 ↗
32. 10.1002/adma.20180396110.1002/adma.201803961 ↗
33. 10.1002/adma.20180129110.1002/adma.201801291 ↗
34. 10.1038/s41928-018-0103-310.1038/s41928-018-0103-3 ↗
35. 10.1126/science.aao009810.1126/science.aao0098 ↗
36. 10.1038/ncomms1544810.1038/ncomms15448 ↗
37. Qian C. · Adv. Funct. Mater. · 2022 · 32
38. 10.1021/acsmaterialslett.1c0058610.1021/acsmaterialslett.1c00586 ↗
39. 10.1002/adma.20210272510.1002/adma.202102725 ↗
40. 10.1021/acsnano.0c0771910.1021/acsnano.0c07719 ↗
41. 10.1021/acsami.9b1120610.1021/acsami.9b11206 ↗
42. 10.1021/acs.chemmater.7b0346010.1021/acs.chemmater.7b03460 ↗
43. 10.1016/j.tsf.2004.05.02910.1016/j.tsf.2004.05.029 ↗