Menin Reduces Parvalbumin Expression and is Required for the Anti‐Depressant Function of Ketamine
Source abstract
Abstract
Abstract Dysfunction of parvalbumin (PV) neurons is closely involved in depression, however, the detailed mechanism remains unclear. Based on the previous finding that multiple endocrine neoplasia type 1 (Protein: Menin; Gene: Men1) mutation (G503D) is associated with a higher risk of depression, a Menin‐G503D mouse model is generated that exhibits heritable depressive‐like phenotypes and increases PV expression in brain. This study generates and screens a serial of neuronal specific Men1 deletion mice, and found that PV interneuron Men1 deletion mice (PcKO) exhibit increased cortical PV levels and depressive‐like behaviors. Restoration of Menin, knockdown PV expression or inhibition of PV neuronal activity in PV neurons all can ameliorate the depressive‐like behaviors of PcKO mice. This study next found that ketamine stabilizes Menin by inhibiting protein kinase A (PKA) activity, which mediates the anti‐depressant function of ketamine. These results demonstrate a critical role for Menin in depression, and prove that Menin is key to the antidepressant function of ketamine.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Receptor Mechanisms and Signaling · Neuroscience and Neuropharmacology Research · Tryptophan and brain disorders
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Institute of Neuroscience Department of Anesthesiology The First Affiliated Hospital of Xiamen University School of Medicine Xiamen University Xiamen Fujian 361102 P. R. China
Shanghai Mental Health Center Shanghai Jiaotong University School of Medicine Shanghai 200030 P. R. China
Department of Geriatrics Xiang'an Hospital of Xiamen university Xiamen Fujian 361102 P. R. China
State Key Laboratory of Medical Molecular Biology Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical College Neuroscience Center Chinese Academy of Medical Sciences Beijing 100730 P. R. China
Funding
National Natural Science Foundation of China · National Key Research and Development Program of China · Fundamental Research Funds for the Central Universities · Natural Science Foundation of Fujian Province
References (67)
Show source-provided references
1. 10.1001/archpsyc.62.10.109710.1001/archpsyc.62.10.1097 ↗
2. 10.1016/S0140-6736(15)60692-410.1016/S0140-6736(15)60692-4 ↗
3. 10.1038/mp.2012.2110.1038/mp.2012.21 ↗
4. 10.1176/appi.ajp.157.10.155210.1176/appi.ajp.157.10.1552 ↗
5. 10.1016/S0140-6736(17)32802-710.1016/S0140-6736(17)32802-7 ↗
6. 10.1038/mp.2010.3810.1038/mp.2010.38 ↗
7. 10.1038/s41588-018-0090-310.1038/s41588-018-0090-3 ↗
8. 10.1038/s41398-019-0450-510.1038/s41398-019-0450-5 ↗
9. 10.1038/ng.340610.1038/ng.3406 ↗
10. 10.1016/j.tibs.2013.05.00510.1016/j.tibs.2013.05.005 ↗
11. 10.1093/jjco/27.6.41910.1093/jjco/27.6.419 ↗
12. 10.1016/j.neuron.2018.08.03110.1016/j.neuron.2018.08.031 ↗
13. 10.1530/ERC-17-029810.1530/ERC-17-0298 ↗
14. 10.1038/onc.2009.27310.1038/onc.2009.273 ↗
15. 10.1016/S1097-2765(04)00081-410.1016/S1097-2765(04)00081-4 ↗
16. 10.1158/0008-5472.CAN-12-315810.1158/0008-5472.CAN-12-3158 ↗
17. Wu T. · Am. J. Cancer Res. · 2011 · 1 · 726
18. 10.1126/science.107699710.1126/science.1076997 ↗
19. 10.3389/fncel.2019.0008710.3389/fncel.2019.00087 ↗
20. 10.1016/j.ejphar.2019.02.02410.1016/j.ejphar.2019.02.024 ↗
21. 10.1016/j.cell.2017.06.01510.1016/j.cell.2017.06.015 ↗
22. 10.1016/j.biopsych.2016.03.210110.1016/j.biopsych.2016.03.2101 ↗
23. 10.1038/nature1135610.1038/nature11356 ↗
24. 10.1007/s12035-017-0528-010.1007/s12035-017-0528-0 ↗
25. 10.1016/j.bbr.2020.11250910.1016/j.bbr.2020.112509 ↗
26. 10.1038/s41586-020-03047-010.1038/s41586-020-03047-0 ↗
27. 10.1016/S0006-3223(99)00230-910.1016/S0006-3223(99)00230-9 ↗
28. 10.1001/archpsyc.63.8.85610.1001/archpsyc.63.8.856 ↗
29. 10.1016/j.biopsych.2014.03.02610.1016/j.biopsych.2014.03.026 ↗
30. 10.1136/bmj.l557210.1136/bmj.l5572 ↗
31. 10.1073/pnas.151391311210.1073/pnas.1513913112 ↗
32. 10.1152/jn.1999.81.4.190310.1152/jn.1999.81.4.1903 ↗
33. 10.1523/JNEUROSCI.2213-07.200710.1523/JNEUROSCI.2213-07.2007 ↗
34. 10.1523/JNEUROSCI.21-18-07261.200110.1523/JNEUROSCI.21-18-07261.2001 ↗
35. 10.1093/cercor/bhj00210.1093/cercor/bhj002 ↗
36. 10.1016/j.biopsych.2019.11.01410.1016/j.biopsych.2019.11.014 ↗
37. 10.1016/j.celrep.2018.06.05510.1016/j.celrep.2018.06.055 ↗
38. 10.1007/s00429-019-02011-710.1007/s00429-019-02011-7 ↗
39. 10.1073/pnas.070029310410.1073/pnas.0700293104 ↗
40. 10.1016/j.neuron.2020.07.03910.1016/j.neuron.2020.07.039 ↗
41. 10.30773/pi.2019.023610.30773/pi.2019.0236 ↗
42. 10.1083/jcb.20180504910.1083/jcb.201805049 ↗
43. 10.1016/j.euroneuro.2015.04.02510.1016/j.euroneuro.2015.04.025 ↗
44. 10.1016/j.neulet.2012.09.03210.1016/j.neulet.2012.09.032 ↗
45. 10.1038/mp.2014.6810.1038/mp.2014.68 ↗
46. 10.1016/j.biopsych.2009.09.02510.1016/j.biopsych.2009.09.025 ↗
47. 10.1159/00011936310.1159/000119363 ↗
48. 10.1038/mp.2010.12010.1038/mp.2010.120 ↗
49. 10.1016/j.neuropharm.2011.08.04010.1016/j.neuropharm.2011.08.040 ↗
50. 10.1016/j.neuroscience.2016.06.03810.1016/j.neuroscience.2016.06.038 ↗
51. 10.1007/s00429-012-0479-110.1007/s00429-012-0479-1 ↗
52. 10.1016/j.pbb.2018.10.00510.1016/j.pbb.2018.10.005 ↗
53. 10.1101/sqb.2018.83.03763010.1101/sqb.2018.83.037630 ↗
54. 10.1038/nature1286610.1038/nature12866 ↗
55. 10.1038/nrn325810.1038/nrn3258 ↗
56. 10.1038/s41380-021-01355-z10.1038/s41380-021-01355-z ↗
57. 10.1186/s13041-016-0192-810.1186/s13041-016-0192-8 ↗
58. 10.1111/j.1399-5618.2009.00785.x10.1111/j.1399-5618.2009.00785.x ↗
59. 10.1007/s12035-014-8798-210.1007/s12035-014-8798-2 ↗
60. 10.18632/oncotarget.1540510.18632/oncotarget.15405 ↗
61. 10.1016/j.bbr.2011.02.02410.1016/j.bbr.2011.02.024 ↗
62. 10.1038/nature1013010.1038/nature10130 ↗
63. 10.1128/MCB.23.17.6075-6085.200310.1128/MCB.23.17.6075-6085.2003 ↗
64. 10.1371/journal.pone.003594310.1371/journal.pone.0035943 ↗
65. 10.1007/s00335-004-2395-z10.1007/s00335-004-2395-z ↗
66. 10.1038/1270310.1038/12703 ↗
67. 10.1101/gad.13.23.313610.1101/gad.13.23.3136 ↗