Functionalizing Collagen with Vessel‐Penetrating Two‐Photon Phosphorescence Probes: A New In Vivo Strategy to Map Oxygen Concentration in Tumor Microenvironment and Tissue Ischemia
Source abstract
Abstract
Abstract The encapsulation and/or surface modification can stabilize and protect the phosphorescence bio‐probes but impede their intravenous delivery across biological barriers. Here, a new class of biocompatible rhenium (ReI) diimine carbonyl complexes is developed, which can efficaciously permeate normal vessel walls and then functionalize the extravascular collagen matrixes as in situ oxygen sensor. Without protective agents, ReI‐diimine complex already exhibits excellent emission yield (34%, λem = 583 nm) and large two‐photon absorption cross‐sections (σ2 = 300 GM @ 800 nm) in water (pH 7.4). After extravasation, remarkably, the collagen‐bound probes further enhanced their excitation efficiency by increasing the deoxygenated lifetime from 4.0 to 7.5 µs, paving a way to visualize tumor hypoxia and tissue ischemia in vivo. The post‐extravasation functionalization of extracellular matrixes demonstrates a new methodology for biomaterial‐empowered phosphorescence sensing and imaging.
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Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Luminescence and Fluorescent Materials · Nonlinear Optical Materials Studies
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Chemistry National Taiwan University Taipei 10617 Taiwan
Department of Chemistry University of Eastern Finland Joensuu 80101 Finland
St.‐Petersburg State University 7/9 Universitetskaya nab St.‐Petersburg 199034 Russia
Department of Dermatology National Taiwan University Hospital and National Taiwan University College of Medicine Taipei 10002 Taiwan
Department of Bioinformatics and Medical Engineering Asia University Taichung City 41354 Taiwan
3D Printing Medical Research Institute Asia University Taichung City 41354 Taiwan
Institute of Translational Medicine, Faculty of Health Sciences Ministry of Education Frontiers Science Center for Precision Oncology University of Macau Taipa Macau 999078 China
Funding
Academy of Finland · Russian Science Foundation · Universidade de Macau · University of Louisville · Ministry of Science and Technology, Taiwan
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