DataVXAdvanced SciencePaper
journal article·2019-02Open access

Alzheimer's Disease: Microenvironment Remodeling Micelles for Alzheimer's Disease Therapy by Early Modulation of Activated Microglia (Adv. Sci. 4/2019)

Yifei Lu, Zhongyuan Guo, Yujie Zhang, Chao Li, Yu Zhang, Qin Guo, Qinjun Chen, Xinli Chen, Xi He, Lisha Liu, Chunhui Ruan, Tao Sun, Bin Ji, Weigen Lu, Chen Jiang

Advanced Science· Volume 6· Issue 4
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Source abstract

Abstract

An Alzheimer's disease (AD) brain is featured with the oxidative and inflammatory microenvironment caused by overactivated microglia. In article number 1801586, Chen Jiang and co-workers design a brain normalizing system to eliminate reactive oxygen species (ROS) and reeducate microglia from an early phase of AD. Through its efficient neuroprotection and microglia modulatory functions, decreased Aβ plaque burdens and improved cognition are achieved.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Neurological Disease Mechanisms and Treatments · Neuroinflammation and Neurodegeneration Mechanisms

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Key Laboratory of Smart Drug Delivery Ministry of Education State Key Laboratory of Medical Neurobiology Research Center on Aging and Medicine Department of Pharmaceutics School of Pharmacy Fudan University Shanghai 201203 China

Department of Functional Brain Imaging Research National Institute of Radiological Sciences National Institute for Quantum and Radiological Science and Technology Chiba 263‐8555 Japan

National Pharmaceutical Engineering and Research Center China State Institute of Pharmaceutical Industry Shanghai 201203 China

References

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