journal article·2021-08Open access

Intravital Whole‐Process Monitoring Thermo‐Chemotherapy Via 2D Silicon Nanoplatform: A Macro Guidance and Long‐Term Microscopic Precise Imaging Strategy

Doudou Huang, Guangxing Wang, Jingsong Mao, Chunlei Liu, Zhongxiong Fan, Yunrui Zhang, Bei Zhang, Yang Zhao, Cuixia Dai, Yaqin He, Heng Ma, Gang Liu, Xiaoyuan Chen, Qingliang Zhao

Advanced Science· Volume 8· Issue 16

Abstract

Abstract Tumor angiogenesis is a complex process that is unamenable to intravital whole‐process monitoring, especially on microscopic assessment of tumor microvessel and quantifying microvascular hemodynamics before and after the nanotherapeutics, which hinder the understanding of nanotheranostics outcomes in tumor treatment. Herein, a new photoacoustic (PA) imaging‐optical coherence tomography angiography (OCTA)‐laser speckle (LS) multimodal imaging strategy is first proposed, which is not only able to precisely macro guide the thermo‐chemotherapy of tumor by monitoring blood oxygen saturation (SaO2) and hemoglobin content (HbT), but also capable of long‐term microscopic investigating the microvessel morphology (microvascular density) and hemodynamics changes (relative blood flow) before and after the nanotherapeutics in vivo. Moreover, to realize the tumor thermo‐chemotherapy treatment based on this novel multimodal imaging strategy, a 2D 5‐fluorouracil silicon nanosheets (5‐Fu‐Si NSs) therapeutic agent is designed. Furthermore, 2D high‐resolution tumor microvascular images in different stage display that tendency of the thermo‐chemotherapy effect is closely associated with tumor angiogenesis. Taken together, the investigations establish the fundamental base in theory and technology for further tailoring the novel specific diagnosis and treatment strategy in tumor. More importantly, this technique will be beneficial to evaluate the tumor microvascular response to nanotherapeutics at microscale.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Nanoplatforms for cancer theranostics · Photoacoustic and Ultrasonic Imaging · Extracellular vesicles in disease

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics Center for Molecular Imaging and Translational Medicine School of Public Health Xiamen University Xiamen 361102 China

Department of Radiology Xiang'an Hospital of Xiamen University Xiamen 361102 China

Laboratory of Translational Medicine Medical Innovation Research Division of Chinese PLA General Hospital Beijing 100853 China

Department of Biomaterials College of Materials Research Center of Biomedical Engineering of Xiamen & Key Laboratory of Biomedical Engineering of Fujian Province & Fujian Provincial Key Laboratory for Soft Functional Xiamen University Xiamen 361102 China

Department of Mechanical and Electrical Engineering Xiamen University Xiamen 361102 China

College of Physics Shanghai Institute of Technology Shanghai 201418 China

Department of Colorectal Surgery General Hospital of Ningxia Medical University Yinchuan 750004 China

Department of Physiology and Pathophysiology School of Basic Medical Sciences Fourth Military Medical University Xi'an 710032 China

Yong Loo Lin School of Medicine and Faculty of Engineering National University of Singapore Singapore 117597 Singapore

Shenzhen Research Institute of Xiamen University Shenzhen 518063 China

Funding

Natural Science Foundation of Guangdong Province · National Natural Science Foundation of China

References (48)

Show source-provided references
1. 10.1021/acsnano.9b0813310.1021/acsnano.9b08133 ↗
2. 10.1002/smll.20180064410.1002/smll.201800644 ↗
3. 10.2174/187152061966619082014593010.2174/1871520619666190820145930 ↗
4. 10.1021/acsnano.9b0721810.1021/acsnano.9b07218 ↗
5. 10.7150/thno.4516410.7150/thno.45164 ↗
6. 10.1002/smll.20200508610.1002/smll.202005086 ↗
7. 10.1073/pnas.170315111410.1073/pnas.1703151114 ↗
8. 10.1038/ncomms1296710.1038/ncomms12967 ↗
9. 10.1002/ange.20170800510.1002/ange.201708005 ↗
10. 10.1039/C8BM00812D10.1039/C8BM00812D ↗
11. 10.1038/nrc107410.1038/nrc1074 ↗
12. 10.1002/ange.20170365710.1002/ange.201703657 ↗
13. 10.1016/j.talanta.2020.12130810.1016/j.talanta.2020.121308 ↗
14. 10.1002/adfm.20200159310.1002/adfm.202001593 ↗
15. 10.1016/j.mtnano.2018.11.00610.1016/j.mtnano.2018.11.006 ↗
16. 10.1038/nchem.158910.1038/nchem.1589 ↗
17. 10.1002/cssc.20190326010.1002/cssc.201903260 ↗
18. 10.1016/j.jconrel.2016.09.02810.1016/j.jconrel.2016.09.028 ↗
19. 10.1016/j.biomaterials.2020.12063510.1016/j.biomaterials.2020.120635 ↗
20. 10.1021/acsnano.6b0312710.1021/acsnano.6b03127 ↗
21. 10.1002/adfm.20190953910.1002/adfm.201909539 ↗
22. 10.1056/NEJM19710812285071110.1056/NEJM197108122850711 ↗
23. 10.1158/1078-0432.CCR-09-310010.1158/1078-0432.CCR-09-3100 ↗
24. 10.1002/advs.20200278810.1002/advs.202002788 ↗
25. 10.1021/acsnano.0c0308010.1021/acsnano.0c03080 ↗
26. 10.1146/annurev.bioeng.6.040803.14013010.1146/annurev.bioeng.6.040803.140130 ↗
27. 10.1016/j.addr.2020.06.01210.1016/j.addr.2020.06.012 ↗
28. 10.1002/smll.20190234610.1002/smll.201902346 ↗
29. 10.1002/adhm.20180029910.1002/adhm.201800299 ↗
30. 10.1016/S0006-3495(97)78307-310.1016/S0006-3495(97)78307-3 ↗
31. 10.1002/anie.20191412010.1002/anie.201914120 ↗
32. 10.1002/ange.20201511610.1002/ange.202015116 ↗
33. Zhang H. F. · Appl. Phys. Lett. · 2007 · 90 · 1555
34. 10.1016/j.physleta.2007.04.06210.1016/j.physleta.2007.04.062 ↗
35. 10.1016/j.scib.2020.09.02710.1016/j.scib.2020.09.027 ↗
36. 10.1016/j.nanoen.2020.10546510.1016/j.nanoen.2020.105465 ↗
37. 10.1007/s12274-020-3064-610.1007/s12274-020-3064-6 ↗
38. 10.1016/j.biomaterials.2018.04.00210.1016/j.biomaterials.2018.04.002 ↗
39. 10.1038/nnano.2016.28010.1038/nnano.2016.280 ↗
40. 10.1002/advs.20190257610.1002/advs.201902576 ↗
41. 10.1002/adfm.20200071210.1002/adfm.202000712 ↗
42. 10.1016/j.jtbi.2004.01.00910.1016/j.jtbi.2004.01.009 ↗
43. 10.1038/nm98810.1038/nm988 ↗
44. 10.1016/j.semcancer.2017.12.00210.1016/j.semcancer.2017.12.002 ↗
45. Kim H.‐s. · Curr. Opt. Photonics · 2019 · 3 · 54
46. A. F.Frangi W. J.Niessen K. L.Vincken M. A.Viergever presented atInternational Conf. on Medical Image Computing and Computer‐Assisted Intervention Cambridge MA October1998.
47. 10.1016/j.pacs.2019.10015210.1016/j.pacs.2019.100152 ↗
48. 10.1117/1.JBO.21.6.06600810.1117/1.JBO.21.6.066008 ↗