DataVXAdvanced SciencePaper
journal article·2026-01Open access

Nanogel Integrated Zwitterionic Injectable Hydrogel with Sequential Drug‐Releasing Capability for the Programmable Repair of Spinal Cord Injury

Zhijian Wei, Susu Huang, Wencan Zhang, Jiayao Wen, Xiaolong Zhou, Wei He, Xiaoye Yang, Haifeng Wang, Guangxi Zhai, Bin Shi, Lin Jin, Dachuan Wang, Shiqing Feng, Lei Ye

Advanced Science· Volume 13· Issue 6
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Source abstract

Abstract

Abstract Spinal cord injury (SCI), a highly disabling injury to the central nervous system, has a complex and sequential pathogenesis. Traditional multiple‐delivery systems rely on a physical mix of nanoparticles or drugs in hydrogels, which lacks the controllability of the drug. To solve these problems, an integrative hydrogel system cross‐linked with a Per‐g‐PSB nanogel is designed. Dendritic macromolecular nanogels (Per‐g‐PSB) could not only act as cross‐linkers to adjust the hydrogel mechanical properties but also form a dynamic network (Dex/Per‐g‐PSB hydrogel). Most importantly, a large amount of charge could lead to a significant sustained release via electrostatic interactions. The hydrogel platform (Mel/Ibu@D/P‐g‐PSB) realizes the sequential release of melatonin and ibuprofen by different mechanisms. Melatonin is first released by diffusion and exhibits significant neuroprotective effects during the acute phase by downregulating the expression of inflammatory cytokines. Ibuprofen is released in the second stage due to strong electrostatic interactions, and it reduces RhoA signaling activation by blocking the ROCK pathway in the subacute phase, which reduces the deleterious cascade reaction after spinal cord injury. These results show that the ion‐sensitive hydrogel platform with sequentially releasing drug effects, combining anti‐inflammatory effects and blocking the ROCK pathway, shows excellent repair of SCI.
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Research context

PolymersNanomaterials

OpenAlex topics: Hydrogels: synthesis, properties, applications · Spinal Cord Injury Research · Nerve injury and regeneration

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Orthopaedics Qilu Hospital, Shandong University Centre for Orthopaedics Advanced Medical Research Institute Shandong University Jinan Shandong 250012 China

NMPA Key Laboratory for Technology Research and Evaluation of Drug Products and Key Laboratory of Chemical Biology (Ministry of Education) State Key Laboratory of Discovery and Utilization of Functional Components in Traditional Chinese Medicine Department of Pharmaceutics School of Pharmaceutical Sciences Cheeloo College of Medicine Shandong University No. 44 Wenhua West Road, Lixia District Jinan 250012 China

Department of Pharmacy Zhongshan Hospital Fudan University 180 Fenglin Road Shanghai 200032 China

Department of Orthopaedics The Second Hospital of Shandong University No. 247 Beiyuan Street, Tianqiao District Jinan 250033 China

Neck‐Shoulder and Lumbocrural Pain Hospital of Shandong First Medical University Shandong First Medical University & Shandong Academy of Medical Sciences No. 18877, Jingshi Road, Lixia District Jinan 518873 China

International Joint Research Laboratory for Biomedical Nanomaterials of Henan Zhoukou Normal University No. 6, Middle Section of Wenchang Avenue, Chuanhui District Zhoukou 466001 China

Funding

China Postdoctoral Science Foundation · Taishan Scholar Foundation of Shandong Province

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