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journal article·2026-02Open access

AI‐Guided SERS Defines a Pan‐Cancer Diagnostic Biomarker

Cai Zhang, Wen‐Hui Zhao, Duo Zuo, Tianxing Zhou, Wenjing Hou, Lingwei Wang, Shangheng Shi, Yang Yang, Yuanyuan Liu, Shao‐Kai Sun, Li Ren, Zhaoxiang Ye, Dingbin Liu, Dong Li, Xiaoyuan Chen, Jihui Hao

Advanced Science· Volume 13· Issue 7
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Source abstract

Abstract

Abstract Early and accurate detection of multiple cancers through a single test remains an unmet clinical need, hindered by current limitations in accuracy, throughput, automation, and multiplexing. Here, we present an AI‐powered SERS chip that combines automated exosome capture with AI‐enabled molecular fingerprinting to accurately distinguish ten common cancer types from a single serum test. The system employs a peptide‐functionalized SERS chip enabling the selective enrichment of exosomes directly from patient serum, enhancing label‐free Raman fingerprint signals. AI‐driven spectral analysis achieved 97.4% accuracy in distinguishing cancer from healthy samples, 97.08% accuracy for early‐stage cancer detection, and 93.89% accuracy in classifying ten common cancer types, including breast, thyroid, esophageal, kidney, pancreatic, duodenal, lung, colorectal, ovarian, and gastric cancers. Crucially, based on molecular profiling, we identified exosomal deoxyadenosine triphosphate as a promising pan‐cancer biomarker consistently upregulated across diverse tumor types. This discovery establishes a potential pan‐cancer diagnostic marker, while the fully automated, scalable platform offers significant promise for clinical translation in early and differential cancer diagnosis.
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Research context

OpenAlex topics: Gold and Silver Nanoparticles Synthesis and Applications · Extracellular vesicles in disease · Spectroscopy Techniques in Biomedical and Chemical Research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiology Tianjin Medical University Cancer Institute and Hospital National Clinical Research Centre of Cancer Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Hexi District Tianjin 300060 China

Department of Radiology Tianjin Medical University General Hospital Heping District Tianjin 300052 China

Department of Clinical Laboratory Tianjin Medical University Cancer Institute and Hospital Hexi District Tianjin 300060 China

Department of Pancreatic Cancer Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Key Laboratory of Cancer Prevention and Therapy Tianjin's Clinical Research Center for Cancer Hexi District Tianjin 300060 China

Department of Diagnostic and Therapeutic Ultrasonography Tianjin Medical University Cancer Institute and Hospital National Clinical Research Center for Cancer Hexi District Tianjin 300060 China

School of Medical Imaging Division of Medical Technology Tianjin Key Laboratory of Functional Imaging Tianjin Medical University Hexi District Tianjin 300023 China

College of Chemistry Research Center for Analytical Sciences State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Molecular Recognition and Biosensing Nankai University Nankai District Tianjin 300071 China

Department of Diagnostic Radiology Yong Loo Lin School of Medicine National University of Singapore Singapore 119074 Singapore

Nanomedicine Translational Research Program NUS Center for Nanomedicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117597 Singapore

Clinical Imaging Research Centre Centre for Translational Medicine Yong Loo Lin School of Medicine National University of Singapore Singapore 117599 Singapore

Department of Chemical and Biomolecular Engineering and Biomedical Engineering College of Design and Engineering National University of Singapore Singapore 119074 Singapore

Institute of Molecular and Cell Biology Agency for Science, Technology, and Research (A*STAR) Singapore 138673 Singapore

Funding

National Natural Science Foundation of China · National University of Singapore · National Medical Research Council · National Research Foundation

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