Nature‐Inspired Nanostructures from Multiple‐Species Biomembranes: Rational Engineering and Therapeutic Applications in Tumor‐Targeted Nanomedicine
Source abstract
Abstract
Abstract The advent of nanomedicine is profoundly revolutionizing conventional paradigms in cancer therapeutics. Selected formulations encompassing lipid nanoparticles and polymeric nanoparticles have already attained regulatory approval for clinical treatment. Nonetheless, achieving precise spatiotemporal control of exogenous nanomedicine within intricate physiological environments remains a formidable challenge. Drawing inspiration from evolutionarily optimized natural biological architectures, the development of biomembrane‐derived nanostructures with unique biological activities provides a new impetus for designing personalized antitumor drugs. Biomembrane‐derived constituents, particularly cell membrane, extracellular vesicles, and other bioactive payloads, have inherited their precise targeting, specific tumor killing, and dynamic tumor immunosuppressive microenvironments remodeling properties in antitumor intervention. Here, the diverse biomembrane engineering strategies to equip the biomembrane with plentiful functionalities are highlighted. Moreover, the cutting‐edge innovations of mammalian cells/bacteria/plants‐derived biomembrane nanostructures and their applications for advancing cancer nanomedicine development are systematically reviewed. Finally, the current challenges and future opportunities are proposed to realize the whole potential of biomembrane nanomedicine toward clinical transformation.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Nanoparticle-Based Drug Delivery
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Thoracic Surgery the First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
Key Laboratory of Enhanced Recovery After Surgery of Integrated Chinese and Western Medicine Administration of Traditional Chinese Medicine of Shaanxi Province the First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
Department of Otorhinolaryngology Hospital of Chengdu University of Traditional Chinese Medicine Chengdu Sichuan 610072 P.R. China
Mianyang Key Laboratory of Anesthesia and Neuroregulation Department of Anesthesiology Mianyang Central Hospital Mianyang Sichuan 621000 P. R. China
Department of Biophysics School of Life Science and Technology University of Electronic Science and Technology of China Chengdu Sichuan 610054 P.R. China
School of Basic Medical Sciences Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
Department of Nuclear Medicine The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi 710061 P. R. China
Funding
Shaanxi Province Postdoctoral Science Foundation · National Natural Science Foundation of China · Key Industry Innovation Chain of Shaanxi
References (100+)
Show source-provided references
1. 10.3322/caac.2182610.3322/caac.21826 ↗
2. 10.1186/s12943-023-01801-210.1186/s12943-023-01801-2 ↗
3. 10.1186/s12964-022-00854-y10.1186/s12964-022-00854-y ↗
4. 10.1136/gutjnl-2022-32842810.1136/gutjnl-2022-328428 ↗
5. 10.1038/s41392-023-01536-y10.1038/s41392-023-01536-y ↗
6. 10.1038/s41392-024-01889-y10.1038/s41392-024-01889-y ↗
7. 10.1016/j.jconrel.2012.03.02010.1016/j.jconrel.2012.03.020 ↗
8. 10.1038/nrc.2016.10810.1038/nrc.2016.108 ↗
9. 10.1016/j.addr.2022.11423810.1016/j.addr.2022.114238 ↗
10. 10.1021/acs.accounts.9b0012610.1021/acs.accounts.9b00126 ↗
11. 10.1016/j.actbio.2023.05.04310.1016/j.actbio.2023.05.043 ↗
12. 10.1016/j.apsb.2024.12.00710.1016/j.apsb.2024.12.007 ↗
13. 10.1038/s41578-024-00766-y10.1038/s41578-024-00766-y ↗
14. 10.7150/thno.9709610.7150/thno.97096 ↗
15. Fang R. H. · Nat. Rev. Clin. Oncol. · 2022 · 20 · 1
16. 10.1016/j.copbio.2018.10.00510.1016/j.copbio.2018.10.005 ↗
17. 10.1038/s41551-019-0502-410.1038/s41551-019-0502-4 ↗
18. Song W. · Bioact. Mater. · 2022 · 23 · 80
19. 10.1038/s41579-023-00877-310.1038/s41579-023-00877-3 ↗
20. 10.1016/j.molcel.2024.11.02610.1016/j.molcel.2024.11.026 ↗
21. 10.1002/anie.20240024910.1002/anie.202400249 ↗
22. 10.1021/acsnano.4c0983010.1021/acsnano.4c09830 ↗
23. 10.1016/j.actbio.2023.11.02910.1016/j.actbio.2023.11.029 ↗
24. 10.1021/acsnano.2c1196510.1021/acsnano.2c11965 ↗
25. 10.1038/nature1537310.1038/nature15373 ↗
26. 10.1021/nl500618u10.1021/nl500618u ↗
27. 10.1016/j.addr.2022.11432110.1016/j.addr.2022.114321 ↗
28. 10.1021/acsnano.4c0404510.1021/acsnano.4c04045 ↗
29. Li B. · Nat. Nanotechnol. · 2024 · 19 · 619
30. 10.1016/j.bioactmat.2024.01.02210.1016/j.bioactmat.2024.01.022 ↗
31. 10.1002/smll.20240342210.1002/smll.202403422 ↗
32. 10.1038/nrd397810.1038/nrd3978 ↗
33. 10.1016/j.addr.2021.11391010.1016/j.addr.2021.113910 ↗
34. 10.20517/evcna.2023.1010.20517/evcna.2023.10 ↗
35. 10.1038/nrm.2017.12510.1038/nrm.2017.125 ↗
36. 10.1111/tra.1255810.1111/tra.12558 ↗
37. 10.1016/j.cell.2019.04.02410.1016/j.cell.2019.04.024 ↗
38. Feng J. · Adv. Mater. · 2023 · 35
39. 10.1038/s41573-022-00410-w10.1038/s41573-022-00410-w ↗
40. 10.1038/s44222-024-00255-510.1038/s44222-024-00255-5 ↗
41. Zhao Z. · Extracell. Vesicles Circ. Nucl. Acids · 2021 · 2 · 80
42. 10.1021/acs.nanolett.2c0186310.1021/acs.nanolett.2c01863 ↗
43. 10.1002/anie.20090094210.1002/anie.200900942 ↗
44. 10.1021/acs.analchem.1c0011810.1021/acs.analchem.1c00118 ↗
45. 10.1016/j.biomaterials.2023.12218710.1016/j.biomaterials.2023.122187 ↗
46. 10.1002/adhm.20220109410.1002/adhm.202201094 ↗
47. 10.1002/adma.20210234810.1002/adma.202102348 ↗
48. 10.1016/j.jconrel.2024.03.05510.1016/j.jconrel.2024.03.055 ↗
49. 10.1126/sciadv.adk795510.1126/sciadv.adk7955 ↗
50. 10.1021/ja110926s10.1021/ja110926s ↗
51. 10.1186/s12951-024-02747-310.1186/s12951-024-02747-3 ↗
52. 10.1016/j.biomaterials.2023.12229310.1016/j.biomaterials.2023.122293 ↗
53. 10.1002/advs.20210046010.1002/advs.202100460 ↗
54. 10.1038/s41467-023-40814-910.1038/s41467-023-40814-9 ↗
55. Zhang X. · Nanomicro Lett. · 2021 · 14 · 22
56. 10.1016/j.bioactmat.2023.12.02710.1016/j.bioactmat.2023.12.027 ↗
57. 10.1016/j.bcmd.2010.02.01610.1016/j.bcmd.2010.02.016 ↗
58. 10.1073/pnas.110663410810.1073/pnas.1106634108 ↗
59. 10.1021/acsami.1c1909610.1021/acsami.1c19096 ↗
60. Gao M. · Adv. Mater. · 2017 · 29 · 1429
61. 10.1007/s40820-022-00801-z10.1007/s40820-022-00801-z ↗
62. 10.1002/adfm.20241809010.1002/adfm.202418090 ↗
63. 10.1002/adfm.20160477410.1002/adfm.201604774 ↗
64. 10.1016/j.jconrel.2023.12.05210.1016/j.jconrel.2023.12.052 ↗
65. 10.1186/s12929-022-00866-310.1186/s12929-022-00866-3 ↗
66. 10.1002/EXP.2021016610.1002/EXP.20210166 ↗
67. 10.1016/j.bioactmat.2022.06.01310.1016/j.bioactmat.2022.06.013 ↗
68. 10.1021/acsnano.3c1269410.1021/acsnano.3c12694 ↗
69. 10.1021/acsnano.3c1086210.1021/acsnano.3c10862 ↗
70. 10.1021/acsnano.2c0903310.1021/acsnano.2c09033 ↗
71. Han J. · Nat. Commun. · 2023 · 14
72. Wang K. · Nat. Commun. · 2023 · 14
73. 10.1038/s41565-021-00972-710.1038/s41565-021-00972-7 ↗
74. Kang M. · Adv. Mater. · 2020 · 32
75. 10.1038/s41577-022-00732-110.1038/s41577-022-00732-1 ↗
76. 10.1016/j.bioactmat.2023.08.00110.1016/j.bioactmat.2023.08.001 ↗
77. 10.1021/acsnano.8b0529210.1021/acsnano.8b05292 ↗
78. 10.4252/wjsc.v14.i1.5410.4252/wjsc.v14.i1.54 ↗
79. 10.1021/acsami.3c0117610.1021/acsami.3c01176 ↗
80. 10.1016/j.jcis.2021.05.12610.1016/j.jcis.2021.05.126 ↗
81. 10.1038/s41551-025-01372-110.1038/s41551-025-01372-1 ↗
82. 10.1126/sciadv.adk795510.1126/sciadv.adk7955 ↗
83. 10.1021/acsmaterialslett.2c0061710.1021/acsmaterialslett.2c00617 ↗
84. Liu S. · Bioact. Mater. · 2022 · 22 · 211
85. Yang C. · Adv. Sci. · 2024 · 11
86. 10.1016/j.immuni.2024.07.00910.1016/j.immuni.2024.07.009 ↗
87. Ma X. · Adv. Sci. · 2022 · 9
88. 10.1126/sciadv.adp900910.1126/sciadv.adp9009 ↗
89. 10.1016/j.biomaterials.2024.12299810.1016/j.biomaterials.2024.122998 ↗
90. 10.1126/sciadv.abj820710.1126/sciadv.abj8207 ↗
91. Hong J. · Adv. Mater. · 2021 · 33
92. 10.1016/j.biomaterials.2022.12176510.1016/j.biomaterials.2022.121765 ↗
93. 10.1016/j.cellimm.2020.10426210.1016/j.cellimm.2020.104262 ↗
94. 10.1016/j.immuni.2019.01.01010.1016/j.immuni.2019.01.010 ↗
95. 10.2147/OTT.S28345910.2147/OTT.S283459 ↗
96. 10.1186/s13046-019-1487-210.1186/s13046-019-1487-2 ↗
97. 10.1016/j.lfs.2020.11836910.1016/j.lfs.2020.118369 ↗
98. Zhang Y. · Nat. Nanotechnol. · 2024 · 19
99. Park J. Y. · Adv. Mater. · 2023 · 35
100. 10.1002/jev2.1219810.1002/jev2.12198 ↗