DataVXAdvanced SciencePaper
journal article·2025-11Open access

Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer

Charlie C. H. Ma, Qingqing Liu, Yue Sui, Wutong Du, Kristy W. K. Lam, Jacky W. Y. Lam, Chao Li, Tengteng Chen, Jianwei Sun, Nuomin Li, Ryan T. K. Kwok, Jianping Chen, Feiyi Sun, Ben Zhong Tang

Advanced Science· Volume 12· Issue 43
Publisher pageOpen full text
Source abstract

Abstract

Abstract Breast cancer (BC), characterized by its heterogeneity and diverse subtypes, necessitates personalized treatment strategies. This study presents MF3Ec‐TBPP nanoparticles (NPs) as a promising approach, integrating an aggregation‐induced emission (AIE)‐based photosensitizer, TBPP, with the MF3Ec aptamer to enhance targeted photodynamic therapy (PDT) for Luminal A subtype BC cells. The nanoparticles also feature a 1, 2‐distearoyl‐sn‐glycero‐3‐phosphoethanolamine‐poly(ethylene glycol) shell and dipalmitoyl phosphatidylcholine (DPPC), which stabilize the structure and inhibit singlet oxygen generation, effectively reducing off‐target effects and protecting healthy tissues. Comprehensive in vitro and in vivo studies validate the NPs’ specificity and effectiveness in targeting MCF‐7 BC cells, achieving significant tumor growth inhibition with minimal damage to surrounding tissues. This study highlights the dual functionality of MF3Ec‐TBPP NPs for both diagnosis and treatment, showcasing their potential to improve patient outcomes through precise diagnostic and therapeutic interventions.
Source: crossref · Quality: baseline

Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced biosensing and bioanalysis techniques · Luminescence and Fluorescent Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Chemical and Biological Engineering Department of Chemistry Hong Kong Branch of Chinese National Engineering Research Center for Tissue Restoration and Reconstruction State Key Laboratory of Molecular Neuroscience The Hong Kong University of Science & Technology Hong Kong 999077 P. R. China

School of Chinese Medicine Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong 999077 P. R. China

HKUST‐Shenzhen Research Institute No. 9 Yuexing 1st RD, South Area Hi‐Tech Park, Nanshan Shenzhen 518057 P. R. China

Department of Chemistry The Hong Kong University of Science & Technology Hong Kong 999077 P. R. China

The Ninth Medical Center of Chinese PLA General Hospital Beijing 100101 P. R. China

School of Science and Engineering Shenzhen Institute of Aggregate Science and Technology The Chinese University of Hong Kong, Shenzhen Shenzhen 518172 P. R. China

Funding

Innovation and Technology Commission

References (47)

Show source-provided references
1. Testa U. · Med. Sci. · 2020 · 8 · 18
2. 10.1038/s41523-021-00345-210.1038/s41523-021-00345-2 ↗
3. 10.1093/annonc/mds32610.1093/annonc/mds326 ↗
4. 10.1186/s12885-022-09923-410.1186/s12885-022-09923-4 ↗
5. 10.3390/cancers1506191710.3390/cancers15061917 ↗
6. 10.1093/jnci/djn34410.1093/jnci/djn344 ↗
7. 10.1186/s40644-021-00424-410.1186/s40644-021-00424-4 ↗
8. 10.1007/s10549-013-2620-010.1007/s10549-013-2620-0 ↗
9. 10.4161/cbt.10.10.1387910.4161/cbt.10.10.13879 ↗
10. 10.3390/ijms2502084010.3390/ijms25020840 ↗
11. 10.1186/s12951-016-0241-610.1186/s12951-016-0241-6 ↗
12. 10.1038/s41598-021-87998-y10.1038/s41598-021-87998-y ↗
13. 10.1186/s12951-022-01553-z10.1186/s12951-022-01553-z ↗
14. 10.1021/acs.jmedchem.9b0201410.1021/acs.jmedchem.9b02014 ↗
15. 10.1093/jnci/90.12.88910.1093/jnci/90.12.889 ↗
16. 10.3390/ijms2502102310.3390/ijms25021023 ↗
17. 10.1002/agt2.54010.1002/agt2.540 ↗
18. Shan W. · Aggregate · 2024 · 6
19. 10.3390/pharmaceutics1309133210.3390/pharmaceutics13091332 ↗
20. 10.1021/acs.chemrev.5b0026310.1021/acs.chemrev.5b00263 ↗
21. 10.1039/c1cs15113d10.1039/c1cs15113d ↗
22. 10.1021/acsnano.3c0434210.1021/acsnano.3c04342 ↗
23. 10.1002/agt2.50310.1002/agt2.503 ↗
24. 10.3390/pharmaceutics1508207510.3390/pharmaceutics15082075 ↗
25. 10.1042/BJ2015094210.1042/BJ20150942 ↗
26. 10.1002/smll.20240133410.1002/smll.202401334 ↗
27. 10.1016/j.ejps.2018.09.01310.1016/j.ejps.2018.09.013 ↗
28. 10.1023/A:102013862268610.1023/A:1020138622686 ↗
29. 10.1016/j.ctrv.2013.06.00610.1016/j.ctrv.2013.06.006 ↗
30. 10.1039/D0NR03324C10.1039/D0NR03324C ↗
31. 10.1021/acsami.2c1229110.1021/acsami.2c12291 ↗
32. 10.1016/j.jconrel.2016.01.02010.1016/j.jconrel.2016.01.020 ↗
33. 10.1016/j.addr.2022.11423810.1016/j.addr.2022.114238 ↗
34. 10.1021/acsnano.9b0138310.1021/acsnano.9b01383 ↗
35. T.Lu Version [1.0 (dev 3.2)] http://sobereva.com/soft/Sobtop(accessed: February2024).
36. 10.1021/ct700301q10.1021/ct700301q ↗
37. 10.1063/1.240842010.1063/1.2408420 ↗
38. 10.1063/1.47011710.1063/1.470117 ↗
39. 10.1002/jcc.2003510.1002/jcc.20035 ↗
40. 10.1080/0026897740010017110.1080/00268977400100171 ↗
41. 10.1007/s00214-007-0310-x10.1007/s00214-007-0310-x ↗
42. 10.1063/1.338234410.1063/1.3382344 ↗
43. 10.1021/jp810292n10.1021/jp810292n ↗
44. 10.1103/PhysRevLett.52.99710.1103/PhysRevLett.52.997 ↗
45. Frisch M. J. · Gaussian 16, Revision C.01 · 2016
46. 10.1002/jcc.2288510.1002/jcc.22885 ↗
47. 10.1016/0263-7855(96)00018-510.1016/0263-7855(96)00018-5 ↗