Circadian Rhythm Disruption Exacerbates Autoimmune Uveitis: The Essential Role of PER1 in Treg Cell Metabolic Support for Stability and Function
Source abstract
Abstract
Abstract Circadian rhythm plays a critical role in the progression of autoimmune diseases. While our previous study demonstrated the therapeutic effects of melatonin in experimental autoimmune uveitis, the involvement of circadian rhythm remained unclear. Using a light‐induced circadian rhythm disruption model, we showed that disrupted circadian rhythms exacerbate autoimmune uveitis by impairing the stability and function of Treg cells. Mechanistically, we identified the core clock gene Per1, which is significantly reduced under circadian disruption, is essential for Treg cell metabolism and immunoregulatory function. This study underscores the pivotal role of circadian rhythm‐related Treg cells in autoimmune disease progression.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Circadian rhythm and melatonin · Dietary Effects on Health · Mast cells and histamine
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science Guangzhou 510060 China
Funding
National Natural Science Foundation of China-China Academy of General Technology Joint Fund for Basic Research · Postdoctoral Research Foundation of China
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