Regular versus Irregular Exercise Differentially Modulates Hippocampal‐Hepatic Acetylcholine Flux to Coordinate Fear Memory Extinction and Liver Inflammation (Adv. Sci. 45/2025)

Regular versus Irregular Exercise Regular exercise induces septal cholinergic-hippocampus-vagus nerve circuit aiding fear memory extinction and live protection, whereas irregular exercise lacks the benefit and may cause liver inflammation. The two flying fairies symbolize “exercise,” while the sun and moon at the center represent the “regularity”. The fairy ribbons, connecting the Ruyi (brain circuit) and gourd (liver), symbolizes regular exercise facilitating brain-liver interactions to achieve harmony and unity of mind, body, and humanity. More details can be found in the Research Article by Shuang-Shuang Dai, Man-Tian Mi, and co-workers (DOI: 10.1002/advs.202500177).