journal article·2025-09Open access

Dual‐Crosslinked Betaine‐Based Amphiphilic Hydrogel as a Promising Vitreous Substitute: Anti‐Adhesion, Anti‐Fouling, and Anti‐Cell Proliferation

Yuting Cai, Yun Tan, Jian Cao, Xiaoyuan Zhou, Xingyuan Li, Jianghua Li, Chuntai Liu, Yi Zhang, Yun Li

Advanced Science· Volume 12· Issue 36

Abstract

Abstract Developing an ideal vitreous substitute remains a significant challenge in ophthalmic surgery. This study introduces a novel dual‐crosslinked betaine‐based amphiphilic polymer hydrogel (BAPHs) synthesized via in situ free radical copolymerization. The resulting BAPHs exhibit tunable viscoelasticity, intrinsic self‐healing property, injectability, stable micromorphology, and optical transparency, all modifiable by adjusting the chemical cross‐linker content. When tested in a vitrectomized rabbit model, the BAPHs demonstrated optimal optical properties, mechanical stability, and promising biocompatibility. These results suggest that the BAPHs offer a transformative approach to vitreous substitution, with the potential to overcome the limitations of current clinical materials, offering both structural and functional benefits.
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Research context

OpenAlex topics: Retinal and Macular Surgery · Intraocular Surgery and Lenses · Corneal surgery and disorders

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ophthalmology Hunan Clinical Research Center of Ophthalmic Disease The Second Xiangya Hospital Central South University Changsha 410011 China

Hunan Provincial Key Laboratory of Micro & Nano Materials Interface Science College of Chemistry and Chemical Engineering Central South University Changsha 410083 China

State Key Laboratory of Chemistry and Utilization of Carbon‐Based Energy Resources College of Chemistry Xinjiang University Urumqi Xinjiang 830017 China

Jiangxi Province Division of National Clinical Research Center for Ocular Diseases Jiangxi Clinical Research Center for Ophthalmic Disease, Jiangxi Research Institute of Ophthalmology and Visual Science Affiliated Eye Hospital of Nanchang University Nanchang 330006 China

Key Laboratory of Materials Processing and Old Ministry of Education Zhengzhou University Zhengzhou 50002 China

Key Laboratory of Oil and Gas Fine Chemicals of Ministry of Education College of Chemical Engineering Xinjiang University Urumqi Xinjiang 830017 China

Funding

Basic and Applied Basic Research Foundation of Guangdong Province · Natural Science Foundation of Hunan Province · Department of Science and Technology of Hunan Province · National Natural Science Foundation of China

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