journal article·2025-06Open access

Recent Advances in Xenes Based FET for Biosensing Applications

Huide Wang, Chen Wang, Yule Zhang, Ziqian Wang, Yihan Zhu, Yun Wang, Xiangqian Hong, Han Zhang, Ning Fan, Meng Qiu

Advanced Science· Volume 12· Issue 21

Abstract

Abstract In recent years, monoelemental 2D materials (Xenes) such as graphene, graphdiyne, silicene, phosphorene, and tellurene, have gained significant traction in biosensing applications. Owing to their ultra‐thin layered structure, exceptionally high specific surface area, unique surface electronic properties, excellent mechanical strength, flexibility, and other distinctive features, Xenes are recognized for their potential as materials with low detection limits, high speed, and exceptional flexibility in biosensing applications. In this review, the unique properties of Xenes, their synthesis, and recent theoretical and experimental advances in applications related to biosensing, including DNA/RNA biosensors, protein biosensors, small molecule biosensors, cell, and ion biosensors are comprehensively summarized. Finally, the challenges and prospects of this emerging field are discussed.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: 2D Materials and Applications · MXene and MAX Phase Materials · Graphene research and applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Radio frequency Heterogeneous integration International Collaborative Laboratory of 2D Materials for Optoelectronics Science and Technology Institute for Advanced Study in Nuclear Energy and Safety Interdisciplinary Center of High Magnetic Field Physics of Shenzhen University College of Physics and Optoelectronic Engineering Shenzhen University Shenzhen 518060 China

Key Laboratory of Marine Chemistry Theory and Technology (Ministry of Education) College of Chemistry and Chemical Engineering Ocean University of China Qingdao 266100 China

Shenzhen Eye Hospital Shenzhen Eye Institute Jinan University Shenzhen 518040 China

Funding

Natural Science Foundation of Shandong Province · Department of Education of Guangdong Province · Science, Technology and Innovation Commission of Shenzhen Municipality · Basic and Applied Basic Research Foundation of Guangdong Province · Taishan Scholar Foundation of Shandong Province · Shenzhen Science and Technology Innovation Program · National Natural Science Foundation of China

References (100+)

Show source-provided references
1. 10.1016/j.bios.2019.03.03410.1016/j.bios.2019.03.034 ↗
2. 10.3389/fbioe.2016.0001110.3389/fbioe.2016.00011 ↗
3. Rodbard D. · Diabetes Technol. Ther. · 2016 · 18 · S310.1089/dia.2015.0417 ↗
4. 10.2337/dc18-115010.2337/dc18-1150 ↗
5. 10.1056/NEJM19950223332080710.1056/NEJM199502233320807 ↗
6. 10.1161/JAHA.118.00881910.1161/JAHA.118.008819 ↗
7. 10.1056/NEJM19900614322240310.1056/NEJM199006143222403 ↗
8. 10.1177/221106821558134910.1177/2211068215581349 ↗
9. Bahadır E. B. · 2016
10. 10.1021/acs.chemrev.1c0092410.1021/acs.chemrev.1c00924 ↗
11. 10.1021/ac302401s10.1021/ac302401s ↗
12. 10.1016/j.snb.2019.12736410.1016/j.snb.2019.127364 ↗
13. 10.1016/j.jhazmat.2023.13132410.1016/j.jhazmat.2023.131324 ↗
14. 10.3390/ma1702033310.3390/ma17020333 ↗
15. 10.1016/j.bioelechem.2023.10862310.1016/j.bioelechem.2023.108623 ↗
16. 10.1016/j.microc.2024.11134610.1016/j.microc.2024.111346 ↗
17. 10.1016/j.carbon.2023.11855610.1016/j.carbon.2023.118556 ↗
18. 10.1016/j.talanta.2024.12660410.1016/j.talanta.2024.126604 ↗
19. 10.1016/j.snb.2024.13626210.1016/j.snb.2024.136262 ↗
20. She Z. · Trans. Mater., Biotechnol. Life Sci. · 2024 · 3 · 125
21. 10.1016/j.talanta.2020.12172210.1016/j.talanta.2020.121722 ↗
22. 10.1021/acs.analchem.1c0402210.1021/acs.analchem.1c04022 ↗
23. C.Zhang J.Chen R.Sun Z.Huang Z.Luo C.Zhou M.Wu Y.Duan Y. J. A.Li 2020 5 2977.10.1021/acssensors.0c01453 ↗
24. 10.1039/D0SC06784A10.1039/D0SC06784A ↗
25. 10.1002/smtd.20190046910.1002/smtd.201900469 ↗
26. 10.1116/1.299468810.1116/1.2994688 ↗
27. 10.3390/s2103090610.3390/s21030906 ↗
28. 10.1002/adfm.20230194810.1002/adfm.202301948 ↗
29. 10.1021/ac50062a03510.1021/ac50062a035 ↗
30. 10.1002/advs.20170032310.1002/advs.201700323 ↗
31. 10.1021/acs.chemrev.7b0053610.1021/acs.chemrev.7b00536 ↗
32. 10.1039/C5NR01052G10.1039/C5NR01052G ↗
33. 10.1038/s41928-021-00670-110.1038/s41928-021-00670-1 ↗
34. Wang C. · Nanomaterials · 2022 · 12, 3233
35. 10.1021/acs.nanolett.8b0381810.1021/acs.nanolett.8b03818 ↗
36. 10.1038/s41551-021-00706-z10.1038/s41551-021-00706-z ↗
37. 10.1039/D1TC01463C10.1039/D1TC01463C ↗
38. 10.1002/adma.20210339310.1002/adma.202103393 ↗
39. 10.1021/acs.jpcc.8b0967710.1021/acs.jpcc.8b09677 ↗
40. 10.1021/acsomega.0c0167610.1021/acsomega.0c01676 ↗
41. 10.1016/j.jmst.2022.02.03810.1016/j.jmst.2022.02.038 ↗
42. 10.1039/C8CS00342D10.1039/C8CS00342D ↗
43. 10.1002/anie.20141124610.1002/anie.201411246 ↗
44. 10.1002/adfm.20200288510.1002/adfm.202002885 ↗
45. 10.1039/C8CS00823J10.1039/C8CS00823J ↗
46. 10.1007/s12274-023-5418-310.1007/s12274-023-5418-3 ↗
47. 10.1016/j.nantod.2023.10200710.1016/j.nantod.2023.102007 ↗
48. 10.1021/acs.jpcb.0c0853910.1021/acs.jpcb.0c08539 ↗
49. 10.1021/acsnano.2c1275910.1021/acsnano.2c12759 ↗
50. 10.1088/0953-8984/28/7/07500110.1088/0953-8984/28/7/075001 ↗
51. 10.1002/inf2.1229910.1002/inf2.12299 ↗
52. 10.1021/ja108127r10.1021/ja108127r ↗
53. 10.1021/acsami.9b2078510.1021/acsami.9b20785 ↗
54. 10.1021/acs.chemrev.8b0031110.1021/acs.chemrev.8b00311 ↗
55. 10.1016/j.bios.2019.04.03410.1016/j.bios.2019.04.034 ↗
56. 10.1021/acsbiomaterials.2c0060710.1021/acsbiomaterials.2c00607 ↗
57. 10.1021/acssensors.2c0256210.1021/acssensors.2c02562 ↗
58. 10.1002/adhm.20230056310.1002/adhm.202300563 ↗
59. 10.1073/pnas.231156512010.1073/pnas.2311565120 ↗
60. 10.1021/acssensors.2c0199010.1021/acssensors.2c01990 ↗
61. 10.1016/j.bios.2016.03.05910.1016/j.bios.2016.03.059 ↗
62. 10.1016/j.talanta.2021.12319710.1016/j.talanta.2021.123197 ↗
63. 10.1016/j.electacta.2023.14322810.1016/j.electacta.2023.143228 ↗
64. 10.1021/ac403810g10.1021/ac403810g ↗
65. 10.1021/acs.biochem.9b0096810.1021/acs.biochem.9b00968 ↗
66. 10.1038/s41586-019-1573-910.1038/s41586-019-1573-9 ↗
67. 10.1002/smsc.20230005810.1002/smsc.202300058 ↗
68. 10.1021/acs.analchem.6b0037410.1021/acs.analchem.6b00374 ↗
69. 10.1038/s41586-019-1052-310.1038/s41586-019-1052-3 ↗
70. 10.1016/j.carbon.2022.09.03710.1016/j.carbon.2022.09.037 ↗
71. 10.1021/jacs.2c1365510.1021/jacs.2c13655 ↗
72. 10.1038/nnano.2010.8910.1038/nnano.2010.89 ↗
73. 10.1109/LED.2007.89166810.1109/LED.2007.891668 ↗
74. 10.1002/smll.20230417310.1002/smll.202304173 ↗
75. 10.1016/j.bios.2015.03.01310.1016/j.bios.2015.03.013 ↗
76. 10.1038/nnano.2014.3510.1038/nnano.2014.35 ↗
77. 10.1038/s41467-022-32749-410.1038/s41467-022-32749-4 ↗
78. 10.1002/smll.20210150810.1002/smll.202101508 ↗
79. 10.1002/adma.20160361010.1002/adma.201603610 ↗
80. 10.1039/C6CS00827E10.1039/C6CS00827E ↗
81. 10.1021/acs.analchem.1c0378610.1021/acs.analchem.1c03786 ↗
82. 10.1021/acsnano.0c0282310.1021/acsnano.0c02823 ↗
83. 10.1016/j.jmat.2020.02.00210.1016/j.jmat.2020.02.002 ↗
84. 10.1021/acssensors.8b0034410.1021/acssensors.8b00344 ↗
85. 10.1186/s11671-019-3048-110.1186/s11671-019-3048-1 ↗
86. 10.1002/cjoc.20200058410.1002/cjoc.202000584 ↗
87. 10.1126/science.aao675010.1126/science.aao6750 ↗
88. 10.1002/smll.20110021110.1002/smll.201100211 ↗
89. 10.1021/ja205684a10.1021/ja205684a ↗
90. 10.1021/acsnano.2c1260610.1021/acsnano.2c12606 ↗
91. 10.1021/acs.bioconjchem.8b0059210.1021/acs.bioconjchem.8b00592 ↗
92. 10.1039/b714449k10.1039/b714449k ↗
93. 10.1002/adhm.20180053610.1002/adhm.201800536 ↗
94. 10.1021/nn500914810.1021/nn5009148 ↗
95. 10.1126/sciadv.aar290410.1126/sciadv.aar2904 ↗
96. 10.1021/acs.analchem.5b0466310.1021/acs.analchem.5b04663 ↗
97. 10.1002/advs.20240138610.1002/advs.202401386 ↗
98. 10.1002/smll.20130208110.1002/smll.201302081 ↗
99. 10.1038/s41928-024-01233-w10.1038/s41928-024-01233-w ↗
100. 10.3390/nano1404038210.3390/nano14040382 ↗