Synergistic Modulating of Mitochondrial Transfer and Immune Microenvironment to Attenuate Discogenic Pain
Source abstract
Abstract
Abstract Discogenic pain, caused by intervertebral disc degeneration (IVDD), is a prevalent and challenging condition to treat effectively. Macrophage infiltration with neural ectopic in‐growth resulting from structural disturbances within the intervertebral disc (IVD) is a major cause of discogenic pain. This work systematically reveals how nanoparticles can synergistically regulate the immune microenvironment and mitochondrial communication to attenuate discogenic pain. The antioxidant metal‐polyphenol nanoparticle system can sequentially regulate macrophage phenotype and mitochondrial delivery efficiency. This strategy circumvents the necessity for mitochondrial isolation and preservation techniques that are typically required in conventional mitochondrial transplantation procedures. Furthermore, it facilitates the effective and sustained delivery of mitochondria to damaged cells. In vivo, this nanoparticle formulation effectively preserves the IVD height, maintains the structural integrity of the nucleus pulposus (NP), and restores pain thresholds. Thus, this nanoplatform offers an effective approach to traditional surgical treatments for discogenic pain, with significant potential for clinical application.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Pain Mechanisms and Treatments · Spine and Intervertebral Disc Pathology · Mitochondrial Function and Pathology
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Department of Orthopaedics Key Laboratory of Structural Malformations in Children of Zhejiang Province Key Laboratory of Orthopaedics of Zhejiang Province Rehabilitation Medicine Center The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University Wenzhou 325000 China
Zhejiang Engineering Research Center for Tissue Repair Materials Wenzhou Institute University of Chinese Academy of Sciences Wenzhou 325000 China
Department of Orthopaedics and Traumatology Li Ka Shing Faculty of Medicine The University of Hong Kong Hong Kong SAR China
Spine Unit The Royal Orthopaedic Hospital Birmingham B31 2AP UK
Minimally Invasive Brain and Spine Institute State University of New York Upstate Medical University 475 Irving Ave, #402 Syracuse NY 13210 USA
Department of Orthopedics The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000 China
The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou People's Hospital Quzhou 324000 China
Funding
National Natural Science Foundation of China
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