Actuation‐Mediated Compression of a Mechanoresponsive Hydrogel by Soft Robotics to Control Release of Therapeutic Proteins
Source abstract
Abstract
Abstract Therapeutic proteins, the fastest growing class of pharmaceuticals, are subject to rapid proteolytic degradation in vivo, rendering them inactive. Sophisticated drug delivery systems that maintain protein stability, prolong therapeutic effects, and reduce administration frequency are urgently required. Herein, a mechanoresponsive hydrogel is developed contained within a soft robotic drug delivery (SRDD) device. In a step‐change from previously reported systems, pneumatic actuation of this system releases the cationic therapeutic protein Vascular Endothelial Growth Factor (VEGF) in a bioactive form which is required for therapeutic angiogenesis, the growth of new blood vessels, in numerous clinical conditions. The ability of the SRDD device to release bioactive VEGF in a spatiotemporal manner from the hydrogel is tested in diabetic rats – a model in which angiogenesis is difficult to stimulate. Daily actuation of the SRDD device in the diabetic rat model significantly increased cluster of differentiation 31+ (CD31+) blood vessel number (p = 0.0335) and the diameter of alpha‐smooth muscle actin+ (α‐SMA+) blood vessels (p = 0.0025) compared to passive release of VEGF from non‐actuated devices. The SRDD device combined with the mechanoresponsive hydrogel offers the potential to deliver an array of bioactive therapeutics in a spatiotemporal manner to mimic their natural release in vivo.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: 3D Printing in Biomedical Research · Hydrogels: synthesis, properties, applications · Platelet Disorders and Treatments
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Anatomy and Regenerative Medicine Institute (REMEDI) School of Medicine College of Medicine Nursing and Health Sciences University of Galway Galway H91 W2TY Ireland
Explora‐Bioscience Srl G. Peroni 386 Rome 00131 Italy
Pharmacology and Therapeutics School of Medicine College of Medicine Nursing and Health Sciences University of Galway Galway H91 W2TY Ireland
CÚRAM SFI Research Centre for Medical Devices University of Galway Galway H91 W2TY Ireland
Biomedical Engineering School of Engineering University of Galway Galway H91 HX31 Ireland
Antimicrobial Resistance and Microbial Ecology Group School of Medicine, College of Medicine Nursing and Health Sciences University of Galway Galway H91 DK59 Ireland
Centre for One Health Ryan Institute University of Galway Galway H91 DK59 Ireland
Department of Translational Medicine and Surgery Section of General Pathology, Faculty of Medicine and Surgery Università Cattolica del Sacro Cuore Largo F. Vito Rome 1‐00168 Italy
Institute for Medical Engineering and Science Massachusetts Institute of Technology Cambridge MA 01239 USA
Harvard‐MIT Program in Health Sciences and Technology Cambridge MA 02139 USA
Department of Mechanical Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA
SFI Centre for Advanced Materials and BioEngineering Research Centre (AMBER) Trinity College Dublin Dublin D02 W9K7 Ireland
Funding
Horizon 2020 Framework Programme · Irish Research Council · Science Foundation Ireland
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