DataVXAdvanced SciencePaper
journal article·2025-04Open access

The Placenta Regulates Intrauterine Fetal Growth via Exosomal PPARγ

Xiaofang Luo, Biao Huang, Ping Xu, Hao Wang, Baozhen Zhang, Li Lin, Jiujiang Liao, Mingyu Hu, Xiyao Liu, Jiayu Huang, Yong Fu, Mark D. Kilby, Rodney E. Kellems, Xiujun Fan, Yang Xia, Philip N. Baker, Hongbo Qi, Chao Tong

Advanced Science· Volume 12· Issue 15
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Source abstract

Abstract

Abstract Abnormal adipogenesis is a major contributor to fetal growth restriction (FGR) and its associated complications. However, the underlying etiology remains unclear. Here, it is reported that the placentas of women with pregnancies complicated with FGR exhibit peroxisome proliferator‐activated receptor γ (PPARγ) inactivation. In mice, trophoblast‐specific ablation of murine PPARγ reproduces the phenotype of human fetuses with FGR and defective adipogenesis. Coculture of trophoblasts with preadipocytes significantly improves preadipocyte commitment and differentiation and increases the transcription of a series of adipogenic genes via intercellular transfer of exosomal PPARγ proteins. Moreover, nanoparticle‐mediated placenta‐specific delivery of rosiglitazone (RGZ) significantly rescues adipogenesis defects in an FGR‐induced mouse model. In summary, the placenta is a major reservoir of PPARγ. An insufficient supply of placental PPARγ to fetal preadipocytes via exosomes during late gestation is a major mechanism underlying FGR. Preclinically, placenta‐targeted RGZ administration can be a promising interventional therapy for FGR and/or defective intrauterine fat development.
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Research context

Nanomaterials

OpenAlex topics: Extracellular vesicles in disease · Reproductive System and Pregnancy · Pregnancy and preeclampsia studies

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Reproductive Medicine Center The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China

State Key Laboratory of Maternal and Fetal Medicine of Chongqing Municipality The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China

Ministry of Education International Collaborative Laboratory of Reproduction and Development Chongqing 400016 China

Department of Obstetrics Women and Children's Hospital of Chongqing Medical University Chongqing 401147 China

Department of Biochemistry & Molecular Biology University of Texas McGovern Medical School at Houston Houston TX 77030 USA

Institute of Metabolism and System Research University of Birmingham, and the Fetal Medicine Centre Birmingham Women's and Children's Foundation Trust Edgbaston B15 2TT UK

Shenzhen Institutes of Advanced Technology Chinese Academy of Sciences Shenzhen Guangdong 518055 China

College of Life Sciences University of Leicester Leicester LE1 7RH UK

National Clinical Research Center for Child Health and Disorders Ministry of Education Key Laboratory of Child Development and Disorders Children's Hospital of Chongqing Medical University Chongqing 401122 China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China

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