DataVXAdvanced SciencePaper
journal article·2025-03Open access

Radiotherapy‐Associated Cellular Senescence and EMT Alterations Contribute to Distinct Disease Relapse Patterns in Locally Advanced Cervical Cancer

Lei Zhang, Jun Ma, Jun Zhang, Minjie Hu, Jinlin Cheng, Bin Hu, Junjun Zhou, Di Zhou, Yongrui Bai, Xiumei Ma, Jianming Tang, Haiyan Chen, Ying Jing

Advanced Science· Volume 12· Issue 12
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Source abstract

Abstract

Abstract A notable number of locally advanced cervical carcinoma (LACC) patients experience local or distant disease relapse following radiotherapy. The contribution of tumor microenvironment (TME) to tumor recurrence at different sites remains unclear. Here, single‐nucleus RNA sequencing data from 28 pre‐ and on‐treatment LACC samples from patients with different disease relapse patterns is analyzed. The findings revealed opposing alterations in the expression levels of the cellular senescence pathway after radiotherapy in patients with local and distant relapses. In contrast, an increase in the expression of the epithelial‐mesenchymal transition module after radiotherapy in both relapse groups is observed. Cell–cell interactions, drug‐target expression analyses in malignant cells after radiation, and multiplex immunofluorescence of tumor tissue identified interleukin‐1 receptor type I (IL1R1) as a potential therapeutic target. It is demonstrated that combining the IL1R1 inhibitor anakinra with radiation can mitigate the effects of radiation on tumor cells. This study highlights the distinct roles of cellular senescence and EMT in tumor recurrence.
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Research context

OpenAlex topics: Immune cells in cancer · Cancer-related molecular mechanisms research · Single-cell and spatial transcriptomics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiation Oncology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China

Eye Institute Eye & ENT Hospital Shanghai Medical College Fudan University Shanghai 200031 China

Center for Intelligent Medicine Research Greater Bay Area Institute of Precision Medicine (Guangzhou) School of Life Sciences Fudan University Guangzhou 511400 China

State Key Laboratory of Genetic Engineering Center for Evolutionary Biology School of Life Sciences Fudan University Shanghai 200438 China

Department of Radiation Oncology The First Hospital of Lanzhou University Lanzhou University Lanzhou 730000 China

State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Center for Infectious Diseases National Medical Center for Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang 310003 China

Funding

National Natural Science Foundation of China · Science and Technology Commission of Shanghai Municipality · Beijing Xisike Clinical Oncology Research Foundation

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