DataVXAdvanced SciencePaper
journal article·2024-10Open access

Lactylated Apolipoprotein C‐II Induces Immunotherapy Resistance by Promoting Extracellular Lipolysis (Adv. Sci. 38/2024)

Jian Chen, Deping Zhao, Yupeng Wang, Ming Liu, Yuan Zhang, Tingting Feng, Chao Xiao, Huan Song, Rui Miao, Li Xu, Hongwei Chen, Xiaoying Qiu, Yi Xu, Jingxuan Xu, Zelin Cui, Wei Wang, Yanchun Quan, Yifeng Zhu, Chen Huang, Song Guo Zheng, Jian‐yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan

Advanced Science· Volume 11· Issue 38
Publisher pageOpen full text
Source abstract

Abstract

Lysine-Lactylation In article number 2406333, Jian-yuan Zhao, Ting Zhu, Lianhui Sun, Guangjian Fan, and co-workers explore the protein lysine lactylation (Kla) landscape, identifying Kla as a key factor in cancer immunotherapy resistance. The cover illustration depicts a tree resembling human lungs under attack by lactylated proteins crossing the immunotherapy barrier. The authors propose APOC2K70 Ab (Ruyi Jingu Bang) as a potent tool to block this process and enhance sensitivity to immunotherapy.
Source: openalex_inverted_index · Quality: baseline

Research context

OpenAlex topics: Lipid metabolism and disorders · Phagocytosis and Immune Regulation · Cancer, Lipids, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

References

Reference metadata was not supplied for this record.