DataVXAdvanced SciencePaper
journal article·2024-12Open access

Unleashing the Power of Cold Atmospheric Plasma: Inducing Mitochondria Damage‐Mediated Mitotic Catastrophe

Shengjie Peng, Yue Feng, K.N. Yu, Lijun Wu, Guodong Chen, Miaomiao Yang, Lele Zhao, Wei Cao, Qianwen Cui, Lianjun Chen, Quan Li, Yifan Huang, Cheng Cheng, Fengqin Zhu, Wei Han

Advanced Science· Volume 11· Issue 46
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Source abstract

Abstract

Abstract Despite the promise of cold atmospheric plasma (CAP) for cancer treatment, the challenges associated with the treatment of solid tumors and penetration depth limitations remain, restricting its clinical application. Here, biological evidence is provided that the killing effect of CAP treatment is confined to less than 500 µm subcutaneously and the actual biological dose decreased gradually with depth for the first time, indicating that the limited penetration depth has become an urgent problem that demands immediate solutions. Significantly, it is showed that different from high‐dose treatments, CAP decreased the doses to the low‐dose range but still exhibited anti‐tumor effects via mitotic catastrophe. Unlike radiotherapy or chemotherapy, low‐dose CAP treatment induces mitochondrial structural damage and dysfunction, disrupts energy metabolism and redox balance, and results in mitotic catastrophe. Collectively, these findings suggest that better understanding and taking full advantage of the dose‐response gradient effect of CAP is a potential strategy to prompt its clinical application beyond improving CAP penetration.
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Research context

OpenAlex topics: Plasma Applications and Diagnostics · Heme Oxygenase-1 and Carbon Monoxide · Nanoplatforms for cancer theranostics

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Anhui Province Key Laboratory of Medical Physics and Technology Institute of Health and Medical Technology Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei 230031 P. R. China

University of Science and Technology of China Hefei 230026 P. R. China

Teaching and Research Section of Nuclear Medicine School of Basic Medical Sciences Anhui Medical University Hefei 230032 P. R. China

Department of Physics City University of Hong Kong Tat Chee Avenue Kowloon Tong Hong Kong P. R. China

State Key Laboratory in Marine Pollution City University of Hong Kong Tat Chee Avenue Kowloon Tong Hong Kong P. R. China

Institute of Physical Science and Information Technology Anhui University Hefei 230031 P. R. China

Hefei Cancer Hospital Chinese Academy of Sciences Hefei 230031 P. R. China

School of Biology Food and Environment Hefei University Hefei 230601 P. R. China

Department of Radiation Medicine School of Public Health and Management Wenzhou Medical University Wenzhou 325035 P. R. China

Institute of Plasma Physics Hefei Institutes of Physical Science Chinese Academy of Sciences Hefei 230031 P. R. China

Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions and School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Suzhou 215006 P. R. China

Funding

Hong Kong Institute for Advanced Study, City University of Hong Kong · Anhui Provincial Key Research and Development Plan · National Natural Science Foundation of China

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