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journal article·2024-09Open access

Multi‐Omics Analysis by Machine Learning Identified Lysophosphatidic Acid as a Biomarker and Therapeutic Target for Porcine Reproductive and Respiratory Syndrome

Hao Zhang, Fangyu Hu, Ouyang Peng, Yihui Huang, Guangli Hu, Usama Ashraf, Meifeng Cen, Xiaojuan Wang, Qiuping Xu, Chuangchao Zou, Yu Wu, Bibo Zhu, Wentao Li, Qunhui Li, Chujun Li, Chunyi Xue, Yongchang Cao

Advanced Science· Volume 11· Issue 34
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Source abstract

Abstract

Abstract As a significant infectious disease in livestock, porcine reproductive and respiratory syndrome (PRRS) imposes substantial economic losses on the swine industry. Identification of diagnostic markers and therapeutic targets has been a focal challenge in PPRS prevention and control. By integrating metabolomic and lipidomic serum analyses of clinical pig cohorts through a machine learning approach with in vivo and in vitro infection models, lysophosphatidic acid (LPA) is discovered as a serum metabolic biomarker for PRRS virus (PRRSV) clinical diagnosis. PRRSV promoted LPA synthesis by upregulating the autotaxin expression, which causes innate immunosuppression by dampening the retinoic acid‐inducible gene I (RIG‐I) and type I interferon responses, leading to enhanced virus replication. Targeting LPA demonstrated protection against virus infection and associated disease outcomes in infected pigs, indicating that LPA is a novel antiviral target against PRRSV. This study lays a foundation for clinical prevention and control of PRRSV infections.
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Research context

OpenAlex topics: Animal Virus Infections Studies · Peroxisome Proliferator-Activated Receptors · Virus-based gene therapy research

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Sate Key Laboratory of Biocontrol School of Life Sciences Sun Yat‐sen University Guangzhou 510006 China

Department of Medicine Division of Infectious Diseases Stanford University Stanford CA 94305 USA

Bioinformatics and Omics Center Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 China

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou 510120 China

Guangdong Enterprise Key Laboratory for Animal Health and Environmental Control Wen's Foodstuff Group Co. Ltd Yunfu 527439 China

National Key Laboratory of Agricultural Microbiology Huazhong Agricultural University Wuhan 430070 China

Laboratory of Animal Virology College of Veterinary Medicine Huazhong Agricultural University Wuhan 430070 China

The Cooperative Innovation Center for Sustainable Pig Production Huazhong Agricultural University Wuhan 430070 China

Funding

National Natural Science Foundation of China

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