DataVXAdvanced SciencePaper
journal article·2023-12Open access

Clinically Translatable Solid‐State Dye for NIR‐II Imaging of Medical Devices

Deling Li, Hui Shi, Qingrong Qi, Baisong Chang, Yuanwen Jiang, Kun Qian, Xiudong Guan, Peng Kang, Ning Ma, Yuan Zhang, Zeyu Zhang, Xiaojing Shi, Chunrong Qu, Yilei Wu, Weiyu Chen, Hao Chen, Baowang Li, Liangpeng Chen, Ziyang Li, Shunchang Ma, Lingyun Xu, Yanrong Zhang, Jie Tian, Zhenhua Hu, Wang Jia, Zhen Cheng

Advanced Science· Volume 10· Issue 36
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Source abstract

Abstract

Abstract Medical devices are commonly implanted underneath the skin, but how to real‐time noninvasively monitor their migration, integrity, and biodegradation in human body is still a formidable challenge. Here, the study demonstrates that benzyl violet 4B (BV‐4B), a main component in the FDA‐approved surgical suture, is found to produce fluorescence signal in the first near‐infrared window (NIR‐I, 700–900 nm) in polar solutions, whereas BV‐4B self‐assembles into highly crystalline aggregates upon a formation of ultrasmall nanodots and can emit strong fluorescence in the second near‐infrared window (NIR‐II, 1000–1700 nm) with a dramatic bathochromic shift in the absorption spectrum of ≈200 nm. Intriguingly, BV‐4B‐involved suture knots underneath the skin can be facilely monitored during the whole degradation process in vivo, and the rupture of the customized BV‐4B‐coated silicone catheter is noninvasively diagnosed by NIR‐II imaging. Furthermore, BV‐4B suspended in embolization glue achieves hybrid fluorescence‐guided surgery (hybrid FGS) for arteriovenous malformation. As a proof‐of‐concept study, the solid‐state BV‐4B is successfully used for NIR‐II imaging of surgical sutures in operations of patients. Overall, as a clinically translatable solid‐state dye, BV‐4B can be applied for in vivo monitoring the fate of medical devices by NIR‐II imaging.
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Research context

NanomaterialsBiomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Sensor and Energy Harvesting Materials · Vascular Anomalies and Treatments

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Neurosurgery Beijing Tiantan Hospital China National Clinical Research Center for Neurological Diseases Beijing Neurosurgical Institute Capital Medical University Beijing 100070 China

Molecular Imaging Program at Stanford (MIPS) Bio‐X Program, and Department of Radiology Stanford University Stanford CA 94305 USA

State Key Laboratory of Drug Research Molecular Imaging Center Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China

Shandong Laboratory of Yantai Drug Discovery Bohai Rim Advanced Research Institute for Drug Discovery Yantai Shandong 264117 China

Institute of Molecular Medicine College of Life and Health Sciences Northeastern University Shenyang 110000 China

West China School of Pharmacy Sichuan University Chengdu 610041 China

State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 China

Department of Chemical Engineering Stanford University Stanford CA 94305 USA

Interventional Neuroradiology Center Beijing Tiantan Hospital Capital Medical University Beijing 100070 China

CAS Key Laboratory of Molecular Imaging Beijing Key Laboratory of Molecular Imaging The State Key Laboratory of Management and Control for Complex Systems Institute of Automation Chinese Academy of Sciences Beijing 100190 China

School of Artificial Intelligence University of Chinese Academy of Sciences Beijing 100049 China

Beijing Advanced Innovation Center for Big Data‐Based Precision Medicine School of Medicine Beihang University Beijing 100191 China

Funding

National Science Foundation · National Key Research and Development Program of China · Beijing Nova Program · Natural Science Foundation of Beijing Municipality · National Natural Science Foundation of China

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