DataVXAdvanced SciencePaper
journal article·2023-12Open access

Fusing Positive and Negative CT Contrast Nanoagent for the Sensitive Detection of Hepatoma

Xianfu Meng, Jiahao Gao, Yanhong Sun, Fei Duan, Bixue Chen, Guanglei Lv, Huiyan Li, Xingwu Jiang, Yelin Wu, Jiawen Zhang, Xiangming Fang, Zhenwei Yao, Changjing Zuo, Wenbo Bu

Advanced Science· Volume 10· Issue 34
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Source abstract

Abstract

Abstract Positive computed tomography (CT) contrast nanoagent has significant applications in diagnosing tumors. However, the sensitive differentiation between hepatoma and normal liver tissue remains challenging. This challenge arises primarily because both normal liver and hepatoma tissues capture the nanoagent, resulting in similar positive CT contrasts. Here, a strategy for fusing positive and negative CT contrast nanoagent is proposed to detect hepatoma. A nanoagent Hf‐MOF@AB@PVP initially generates a positive CT contrast signal of 120.3 HU in the liver. Subsequently, it can specifically respond to the acidic microenvironment of hepatoma to generate H2, further achieving a negative contrast of −96.0 HU. More importantly, the relative position between the negative and positive signals area is helpful to determine the location of hepatoma and normal liver tissues. The distinct contrast difference of 216.3 HU and relative orientation between normal liver and tumor tissues are meaningful to sensitively distinguish hepatoma from normal liver tissue utilizing CT imaging.
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Research context

Nanomaterials

OpenAlex topics: Nanoparticle-Based Drug Delivery · Nanoplatforms for cancer theranostics · Genetic and Kidney Cyst Diseases

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nuclear Medicine Changhai Hospital Navy Medical University Shanghai 200433 China

Department of Materials Science and State Key Laboratory of Molecular Engineering of Polymers Academy for Engineering and Technology Fudan University Shanghai 200433 China

Department of Radiology Huashan Hospital Fudan University Shanghai 200040 China

Department of Gastroenterology Changhai Hospital Naval Medical University Shanghai 200433 China

Department of Radiology Eye & ENT Hospital of Fudan University Fudan University Shanghai 200031 China

Department of Radiology Wuxi People's Hospital Nanjing Medical University Wuxi 214023 China

Center for Biotechnology and Biomedical Engineering Yiwu Research Institute of Fudan University Yiwu 322000 China

Tongji University Cancer Center Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 China

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