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journal article·2024-11Open access

Two‐Dimensional Atomically Thin Piezoelectric Nanosheets for Efficient Pyroptosis‐Dominated Sonopiezoelectric Cancer Therapy

Ruxi Deng, Chunrong Ren, Xinran Song, Wuyang Wei, Hai Wang, Quanyu Nie, Ying Liu, Pan Li, Li Ding, Meiqi Chang, Yu Chen, Yang Zhou

Advanced Science· Volume 11· Issue 42
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Source abstract

Abstract

Abstract Sonopiezocatalytic therapy is an emerging therapeutic strategy that utilizes ultrasound irradiation to activate piezoelectric materials, inducing polarization and energy band bending to facilitate the generation of reactive oxygen species (ROS). However, the efficient generation of ROS is hindered by the long distance of charge migration from the bulk to the material surface. Herein, atomically thin Bi2O2(OH)(NO3) (AT‐BON) nanosheets are rationally engineered through disrupting the weaker hydrogen bonds within the [OH] and [NO3] layer in the bulk material. The ultrathin structure of AT‐BON piezocatalytic nanosheets shortens the migration distance of carriers, expands the specific surface area, and accelerates the charge transfer efficiency, showcasing a natural advantage in ROS generation. Importantly, the non‐centrosymmetric polar crystal structure grants the nanosheets the ability to separate electron‐hole pairs. Under ultrasonic mechanical stress, Bi2O2(OH)(NO3) nanosheets with the remarkable piezoelectric feature exhibit the desirable in vivo antineoplastic outcomes in both breast cancer model and liver cancer model. Especially, the AT‐BON‐induced ROS bursts lead to the activation of the Caspase‐1‐driven pyroptosis pathway. This study highlights the beneficial impact of bulk material thinning on enhancing ROS generation efficiency and anti‐cancer effects.
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Research context

Nanomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Extracellular vesicles in disease · Perovskite Materials and Applications

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Ultrasound The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. China

Department of Gastroenterology The Third People's Hospital of Chengdu Affiliated Hospital of Southwest Jiaotong University Chengdu Sichuan 610031 P. R. China

Materdicine Lab School of Life Sciences Shanghai University Shanghai 200444 P. R. China

Department of Ultrasound Chongqing Key Laboratory of Ultrasound Molecular Imaging the Second Affiliated Hospital of Chongqing Medical University Chongqing 400010 P. R. China

Department of Medical Ultrasound National Clinical Research Center of Interventional Medicine Shanghai Tenth People's Hospital Tongji University Cancer Center School of Medicine Tongji University Shanghai 200072 P. R. China

Laboratory Center Shanghai Municipal Hospital of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine Shanghai 200071 P. R. China

Shanghai Institute of Materdicine Shanghai 200051 P. R. China

Funding

Key Research and Development Program of Sichuan Province · National Natural Science Foundation of China

References (35)

Show source-provided references
1. 10.1002/adma.20220825610.1002/adma.202208256 ↗
2. 10.1002/ange.20180566410.1002/ange.201805664 ↗
3. 10.1038/s41568-021-00435-010.1038/s41568-021-00435-0 ↗
4. 10.1038/s41467-021-23921-310.1038/s41467-021-23921-3 ↗
5. 10.1002/anie.20170654910.1002/anie.201706549 ↗
6. 10.1039/C6TA04628B10.1039/C6TA04628B ↗
7. 10.1021/acsnano.1c0061610.1021/acsnano.1c00616 ↗
8. 10.1002/adma.20200197610.1002/adma.202001976 ↗
9. 10.1002/adma.20210683810.1002/adma.202106838 ↗
10. 10.1002/adfm.20220812810.1002/adfm.202208128 ↗
11. 10.1016/j.cej.2022.13503910.1016/j.cej.2022.135039 ↗
12. 10.1002/EXP.2022000110.1002/EXP.20220001 ↗
13. 10.1038/s41467-018-03903-810.1038/s41467-018-03903-8 ↗
14. 10.1021/acs.chemrev.8b0067210.1021/acs.chemrev.8b00672 ↗
15. 10.1002/anie.20120142410.1002/anie.201201424 ↗
16. 10.1002/adma.20230064810.1002/adma.202300648 ↗
17. 10.1021/acsnano.2c0196810.1021/acsnano.2c01968 ↗
18. 10.1016/j.nanoen.2021.10686710.1016/j.nanoen.2021.106867 ↗
19. 10.1002/anie.20210631010.1002/anie.202106310 ↗
20. 10.1021/acssuschemeng.7b0322310.1021/acssuschemeng.7b03223 ↗
21. 10.1021/acsanm.2c0096210.1021/acsanm.2c00962 ↗
22. 10.1002/EXP.2021011210.1002/EXP.20210112 ↗
23. Liu X.‐Y. · Colloids Surf. A · 2019 · 580
24. 10.1002/adma.20230064810.1002/adma.202300648 ↗
25. 10.1002/anie.20231721810.1002/anie.202317218 ↗
26. 10.1002/EXP.2021001010.1002/EXP.20210010 ↗
27. 10.1002/ange.20201639910.1002/ange.202016399 ↗
28. 10.1002/EXP.2023010010.1002/EXP.20230100 ↗
29. 10.1038/nature1551410.1038/nature15514 ↗
30. 10.1038/s41577-019-0228-210.1038/s41577-019-0228-2 ↗
31. 10.1038/nature1859010.1038/nature18590 ↗
32. 10.1002/adma.20210817410.1002/adma.202108174 ↗
33. 10.1038/cr.2015.13910.1038/cr.2015.139 ↗
34. 10.1016/j.biomaterials.2019.11932810.1016/j.biomaterials.2019.119328 ↗
35. 10.1002/EXP.2021008310.1002/EXP.20210083 ↗