Cross‐Species Insights into Trophoblast Invasion During Placentation Governed by Immune‐Featured Trophoblast Cells
Source abstract
Abstract
Abstract Proper development of the placenta, the transient support organ forms after embryo implantation, is essential for a successful pregnancy. However, the regulation of trophoblast invasion, which is most important during placentation, remains largely unknown. Here, rats, mice, and pigs are used as biomedical models, used scRNA‐seq to comparatively elucidate the regulatory mechanism of placental trophoblast invasion, and verified it using a human preeclampsia disease model combined with scStereo‐seq. A dual‐featured type of immune‐featured trophoblast (iTrophoblast) is unexpectedly discovered. Interestingly, iTrophoblast only exists in invasive placentas and regulates trophoblast invasion during placentation. In a normally developing placenta, iTrophoblast gradually transforms from an immature state into a functional mature state as it develops. Whereas in the developmentally abnormal preeclamptic placenta, disordered iTrophoblast transformation leads to the accumulation of immature iTrophoblasts, thereby disrupting trophoblast invasion and ultimately leading to the progression of preeclampsia.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Pregnancy and preeclampsia studies · Reproductive System and Pregnancy · Birth, Development, and Health
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
State Key Laboratory of Swine and Poultry Breeding Industry, National Engineering Research Center for Breeding Swine Industry Guangdong Provincial Key Laboratory of Agro‐Animal Genomics and Molecular Breeding College of Animal Science South China Agricultural University Guangzhou 510642 P. R. China
Reproductive Medicine Center Guangdong Provincial Key Laboratory of Reproductive Medicine The First Affiliated Hospital of Sun Yat‐sen University Guangzhou 510080 P. R. China
Guangdong Key Laboratory of Animal Breeding and Nutrition Institute of Animal Science Guangdong Academy of Agricultural Sciences Guangzhou 510640 P. R. China
Yunfu Subcenter of Guangdong Laboratory for Lingnan Modern Agriculture Yunfu 527300 P. R. China
Key Laboratory of South China Modern Biological Seed Industry Ministry of Agriculture and Rural Affairs Guangzhou 510520 P. R. China
Funding
National Key Research and Development Program of China
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