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journal article·2022-04Open access

Image‐Guided Magnetic Thermoseed Navigation and Tumor Ablation Using a Magnetic Resonance Imaging System

Rebecca R. Baker, Christopher Payne, Yichao Yu, Matin Mohseni, John J. Connell, Fangyu Lin, Ian F. Harrison, Paul Southern, Umesh S. Rudrapatna, Daniel J. Stuckey, Tammy L. Kalber, Bernard Siow, Lewis Thorne, Shonit Punwani, Derek K. Jones, Mark Emberton, Quentin A. Pankhurst, Mark F. Lythgoe

Advanced Science· Volume 9· Issue 12
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Abstract

Abstract Medical therapies achieve their control at expense to the patient in the form of a range of toxicities, which incur costs and diminish quality of life. Magnetic resonance navigation is an emergent technique that enables image‐guided remote‐control of magnetically labeled therapies and devices in the body, using a magnetic resonance imaging (MRI) system. Minimally INvasive IMage‐guided Ablation (MINIMA), a novel, minimally invasive, MRI‐guided ablation technique, which has the potential to avoid traditional toxicities, is presented. It comprises a thermoseed navigated to a target site using magnetic propulsion gradients generated by an MRI scanner, before inducing localized cell death using an MR‐compatible thermoablative device. The authors demonstrate precise thermoseed imaging and navigation through brain tissue using an MRI system (0.3 mm), and they perform thermoablation in vitro and in vivo within subcutaneous tumors, with the focal ablation volume finely controlled by heating duration. MINIMA is a novel theranostic platform, combining imaging, navigation, and heating to deliver diagnosis and therapy in a single device.
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Research context

OpenAlex topics: Micro and Nano Robotics · Microfluidic and Bio-sensing Technologies · Radiation Therapy and Dosimetry

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Centre for Advanced Biomedical Imaging Division of Medicine University College London 72 Huntley Street London WC1E 6DD UK

Resonant Circuits Limited 21 Albemarle Street London W1S 4BS UK

Cardiff University Brain Research Imaging Centre Maindy Road Cardiff CF24 4HQ UK

Victor Horsley Department of Neurosurgery The National Hospital for Neurology and Neurosurgery Queen Square London WC1N 3BG UK

Centre for Medical Imaging University College London Charles Bell House, 43‐45 Foley Street London W1W 7TS UK

Division of Surgery and Interventional Science University College London Charles Bell House, 43–45 Foley Street London W1W 7JN UK

UCL Healthcare Biomagnetics Laboratory University College London 21 Albemarle Street London W1S 4BS UK

Funding

Rosetrees Trust · Medical Research Council · Engineering and Physical Sciences Research Council · Alzheimer’s Research UK · Parkinson's UK · Wellcome Trust · British Heart Foundation

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