DataVXAdvanced SciencePaper
journal article·2024-05Open access

Enzyme‐Empowered “Two Birds with One Stone” Strategy for Amplifying Tumor Apoptosis and Metabolic Clearance

Hanyue Li, Yihui Li, Lina Su, Ke Zheng, Yue Zhang, Jing Li, Feng Lv, Mengjie Huang, Ting Chen, Hanjie Zhang, Zhaoqing Shi, Dunwan Zhu, Xia Dong, Weiwei Zeng, Lin Mei

Advanced Science· Volume 11· Issue 18
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Source abstract

Abstract

Abstract Nanomedicine has reshaped the landscape of cancer treatment. However, its efficacy is still hampered by innate tumor defense systems that rely on adenosine triphosphate (ATP) for fuel, including damage repair, apoptosis resistance, and immune evasion. Inspired by the naturally enzymatic reaction of glucose oxidase (GOx) with glucose, here a novel “two birds with one stone” technique for amplifying enzyme‐mediated tumor apoptosis and enzyme‐promoted metabolic clearance is proposed and achieved using GOx‐functionalized rhenium nanoclusters‐doped polypyrrole (Re@ReP‐G). Re@ReP‐G reduces ATP production while increasing H2O2 concentrations in the tumor microenvironment through GOx‐induced enzymatic oxidation, which in turn results in the downregulation of defense (HSP70 and HSP90) and anti‐apoptotic Bcl‐2 proteins, the upregulation of pro‐apoptotic Bax, and the release of cytochrome c. These processes are further facilitated by laser‐induced hyperthermia effect, ultimately leading to severe tumor apoptosis. As an enzymatic byproduct, H2O2 catalyzes the conversion of rhenium nanoclusters in Re@ReP‐G nanostructures into rhenate from the outside in, which accelerates their metabolic clearance in vivo. This Re@ReP‐G‐based “two birds with one stone” therapeutic strategy provides an effective tool for amplifying tumor apoptosis and safe metabolic mechanisms.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Nanomaterials in Catalysis · Nanoparticle-Based Drug Delivery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

State Key Laboratory of Advanced Medical Materials and Devices Tianjin Key Laboratory of Biomedical Materials Institute of Biomedical Engineering Chinese Academy of Medical Sciences and Peking Union Medical College Tianjin 300192 P. R. China

Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Guangdong‐Hong Kong Joint Laboratory for RNA Medicine Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou 510120 P. R. China

Department of Pharmacy Qujing Medical College Qujing 655000 P. R. China

School of Materials Science and Engineering Dongguan University of Technology Dongguan 523808 P. R. China

Department of Nephrology First Medical Center of Chinese PLA General Hospital National Key Laboratory of Kidney Diseases National Clinical Research Center for Kidney Diseases Beijing Key Laboratory of Kidney Diseases Research Beijing 100853 P. R. China

Funding

National Key Research and Development Program of China · National Natural Science Foundation of China · Fundamental Research Funds for the Central Universities · Science Fund for Distinguished Young Scholars of Tianjin Municipality · Excellent Young Scientists Fund

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