DataVXAdvanced SciencePaper
journal article·2023-04Open access

Low‐Cost, High‐Pressure‐Synthesized Oxygen‐Entrapping Materials to Improve Treatment of Solid Tumors

Jianling Bi, Emily Witt, Vanessa A. Voltarelli, Vivian R. Feig, Veena Venkatachalam, Hannah Boyce, Megan McGovern, Wade R. Gutierrez, Jeffrey D. Rytlewski, Kate R. Bowman, Ashley C. Rhodes, Austin N. Cook, Benjamin N. Muller, Matthew G. Smith, Alexis Rebecca Ramos, Heena Panchal, Rebecca D. Dodd, Michael D. Henry, Adam Mailloux, Giovanni Traverso, Leo E. Otterbein, James D. Byrne

Advanced Science· Volume 10· Issue 10
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Source abstract

Abstract

Abstract Tumor hypoxia drives resistance to many cancer therapies, including radiotherapy and chemotherapy. Methods that increase tumor oxygen pressures, such as hyperbaric oxygen therapy and microbubble infusion, are utilized to improve the responses to current standard‐of‐care therapies. However, key obstacles remain, in particular delivery of oxygen at the appropriate dose and with optimal pharmacokinetics. Toward overcoming these hurdles, gas‐entrapping materials (GeMs) that are capable of tunable oxygen release are formulated. It is shown that injection or implantation of these materials into tumors can mitigate tumor hypoxia by delivering oxygen locally and that these GeMs enhance responsiveness to radiation and chemotherapy in multiple tumor types. This paper also demonstrates, by comparing an oxygen (O2)‐GeM to a sham GeM, that the former generates an antitumorigenic and immunogenic tumor microenvironment in malignant peripheral nerve sheath tumors. Collectively the results indicate that the use of O2‐GeMs is promising as an adjunctive strategy for the treatment of solid tumors.
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Research context

Biomaterials

OpenAlex topics: Nanoplatforms for cancer theranostics · Cancer Research and Treatments · Cancer, Hypoxia, and Metabolism

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Radiation Oncology University of Iowa 200 Hawkins Drive Iowa City IA 52242 USA

Department of Biomedical Engineering University of Iowa 200 Hawkins Drive Iowa City IA 52242 USA

Holden Comprehensive Cancer Center University of Iowa Iowa City IA 52242 USA

Department of Surgery Beth Israel Deaconess Medical Center Harvard Medical School 3 Blackfan Circle Boston MA 02215 USA

Division of Gastroenterology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA

David H. Koch Institute for Integrative Cancer Research Massachusetts Institute of Technology 500 Main St Building 76 Cambridge MA 02142 USA

Department of Mechanical Engineering Massachusetts Institute of Technology 77 Massachusetts Ave Cambridge MA 02139 USA

Department of Systems Biology Harvard Medical School 75 Francis St. Boston MA 02115 USA

Department of Radiation Oncology Brigham and Women's Hospital Harvard Medical School 75 Francis St. Boston MA 02115 USA

Department of Chemical Engineering Massachusetts Institute of Technology 25 Ames St. Cambridge MA 02139 USA

Medical Scientist Training Program University of Iowa Iowa City IA 52242 USA

Department of Internal Medicine University of Iowa Iowa City IA 52242 USA

Department of Microbiology and Immunology Carver College of Medicine University of Iowa Iowa City IA 52242 USA

Department of Molecular Physiology and Biophysics Carver College of Medicine University of Iowa Iowa City IA 52242 USA

Funding

Holden Comprehensive Cancer Center, University of Iowa

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