DataVXAdvanced SciencePaper
journal article·2019-10Open access

Biologically Targeted Photo‐Crosslinkable Nanopatch to Prevent Postsurgical Peritoneal Adhesion

Yu Mi, Feifei Yang, Cameron Bloomquist, Youli Xia, Bo Sun, Yanfei Qi, Kyle Wagner, Stephanie A. Montgomery, Tian Zhang, Andrew Z. Wang

Advanced Science· Volume 6· Issue 19
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Source abstract

Abstract

Abstract Peritoneal adhesion occurs in a majority of patients following abdominal surgery and can result in significant side effects and complications. Current strategies to minimize adhesions involve the use of nontargeted anatomical barriers that are either inefficient in protecting injured areas or lacking the adequate residence time to prevent adhesions. Herein, the development of a biologically targeted photo‐crosslinkable nanopatch (pCNP) is reported that can prevent postsurgical adhesion. It is demonstrated that pCNP can form a compact protective barrier over surfaces with exposed collagen IV. Using a rat parietal peritoneal excision adhesion model, it is showed that pCNP is highly effective and safe in preventing postsurgical adhesions. This work presents a novel approach to preventing peritoneal adhesion with nanomaterials.
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Research context

Nanomaterials

OpenAlex topics: Intestinal and Peritoneal Adhesions · Hernia repair and management · Thyroid and Parathyroid Surgery

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Laboratory of Nano‐ and Translational Medicine Carolina Center for Cancer Nanotechnology Excellence Carolina Institute of Nanomedicine Lineberger Comprehensive Cancer Center Department of Radiation Oncology University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences & Peking Union Medical College Haidian District Beijing 100193 P. R. China

School of Pharmacy University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Department of Genetics University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

School of Public Health Jilin University Changchun Jilin 130021 P. R. China

Department of Pathology and Laboratory Medicine University of North Carolina at Chapel Hill Chapel Hill NC 27599 USA

Department of Medical Oncology Department of Medicine Duke University Medical Center Durham NC 27710 USA

Funding

National Science Foundation

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