journal article·2023-04Open access

Regeneration of Humeral Head Using a 3D Bioprinted Anisotropic Scaffold with Dual Modulation of Endochondral Ossification

Tao Li, Zhengjiang Ma, Yuxin Zhang, Zezheng Yang, Wentao Li, Dezhi Lu, Yihao Liu, Lei Qiang, Tianchang Wang, Ya Ren, Wenhao Wang, Hongtao He, Xiaojun Zhou, Yuanqing Mao, Junfeng Zhu, Jinwu Wang, Xiaodong Chen, Kerong Dai

Advanced Science· Volume 10· Issue 12

Abstract

Abstract Tissue engineering is theoretically thought to be a promising method for the reconstruction of biological joints, and thus, offers a potential treatment alternative for advanced osteoarthritis. However, to date, no significant progress is made in the regeneration of large biological joints. In the current study, a biomimetic scaffold for rabbit humeral head regeneration consisting of heterogeneous porous architecture, various bioinks, and different hard supporting materials in the cartilage and bone regions is designed and fabricated in one step using 3D bioprinting technology. Furthermore, orchestrated dynamic mechanical stimulus combined with different biochemical cues (parathyroid hormone [PTH] and chemical component hydroxyapatite [HA] in the outer and inner region, respectively) are used for dual regulation of endochondral ossification. Specifically, dynamic mechanical stimulus combined with growth factor PTH in the outer region inhibits endochondral ossification and results in cartilage regeneration, whereas dynamic mechanical stimulus combined with HA in the inner region promotes endochondral ossification and results in efficient subchondral bone regeneration. The strategy established in this study with the dual modulation of endochondral ossification for 3D bioprinted anisotropic scaffolds represents a versatile and scalable approach for repairing large joints.
Source: crossref · Quality: baseline

Research context

OpenAlex topics: Osteoarthritis Treatment and Mechanisms · 3D Printing in Biomedical Research · Knee injuries and reconstruction techniques

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Shanghai Key Laboratory of Orthopaedic Implant Department of Orthopaedic Surgery Shanghai Ninth People's Hospital Affiliated Shanghai Jiao Tong University School of Medicine 639 Zhizaoju Rd Shanghai 200011 China

Department of Orthopaedics Xinhua Hospital affiliated to Shanghai Jiaotong University School of Medicine No. 1665 Kongjiang Road Shanghai 200092 P. R. China

Department of Oral Surgery Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine College of Stomatology Shanghai Jiao Tong University National Center for Stomatology National Clinical Research Center for Oral Diseases Shanghai Key Laboratory of Stomatology Shanghai 200011 China

Department of Orthopedics The Fifth People's Hospital of Shanghai Fudan University Minhang District Shanghai 200240 P. R. China

School of Medicine Shanghai University Jing An District Shanghai 200444 China

Southwest JiaoTong University College of Medicine No. 111 North 1st Section of Second Ring Road Chengdu 610036 China

The Third Ward of Department of Orthopedics The Second Hospital of Dalian Medical University No. 467, Zhongshan Road, Shahekou District Dalian Liaoning Province 116000 P. R. China

College of Biological Science and Medical Engineering State Key Laboratory for Modification of Chemical Fibers and Polymer Materials Donghua University Shanghai 201620 P. R. China

Funding

National Natural Science Foundation of China

References (76)

Show source-provided references
1. 10.1002/art.2317710.1002/art.23177 ↗
2. 10.1007/s00167-011-1631-910.1007/s00167-011-1631-9 ↗
3. 10.1042/BC2004010010.1042/BC20040100 ↗
4. 10.2106/JBJS.D.0210410.2106/JBJS.D.02104 ↗
5. 10.1023/B:ABME.0000032454.53116.ee10.1023/B:ABME.0000032454.53116.ee ↗
6. 10.1053/joms.2001.2049110.1053/joms.2001.20491 ↗
7. 10.2106/00004623-199903000-0000210.2106/00004623-199903000-00002 ↗
8. 10.1089/ten.tea.2008.065310.1089/ten.tea.2008.0653 ↗
9. 10.1016/j.actbio.2019.04.01710.1016/j.actbio.2019.04.017 ↗
10. 10.1016/j.biomaterials.2019.01.01310.1016/j.biomaterials.2019.01.013 ↗
11. 10.1002/adhm.20180129810.1002/adhm.201801298 ↗
12. 10.1038/nbt.341310.1038/nbt.3413 ↗
13. 10.1126/scitranslmed.aao075010.1126/scitranslmed.aao0750 ↗
14. 10.1016/j.msec.2020.11138810.1016/j.msec.2020.111388 ↗
15. 10.1088/1758-5090/ab870810.1088/1758-5090/ab8708 ↗
16. 10.1002/adhm.20170029810.1002/adhm.201700298 ↗
17. 10.1016/j.biomaterials.2019.11953610.1016/j.biomaterials.2019.119536 ↗
18. 10.1002/biot.20200009510.1002/biot.202000095 ↗
19. 10.1088/1758-5090/ab262210.1088/1758-5090/ab2622 ↗
20. 10.1016/j.actbio.2019.11.04610.1016/j.actbio.2019.11.046 ↗
21. 10.3727/00000000478398374710.3727/000000004783983747 ↗
22. 10.1038/nrrheum.2013.10910.1038/nrrheum.2013.109 ↗
23. 10.1111/j.1749-6632.1990.tb42363.x10.1111/j.1749-6632.1990.tb42363.x ↗
24. 10.1016/j.joca.2011.12.00310.1016/j.joca.2011.12.003 ↗
25. 10.1073/pnas.130270311110.1073/pnas.1302703111 ↗
26. 10.1002/term.191810.1002/term.1918 ↗
27. 10.1016/j.actbio.2017.09.00310.1016/j.actbio.2017.09.003 ↗
28. 10.1073/pnas.071166210510.1073/pnas.0711662105 ↗
29. 10.1089/ten.teb.2014.041910.1089/ten.teb.2014.0419 ↗
30. 10.1088/0957-4484/27/41/41400110.1088/0957-4484/27/41/414001 ↗
31. 10.2741/445210.2741/4452 ↗
32. Angele P. · Biorheology · 2004 · 41 · 335
33. 10.1089/scd.2008.003010.1089/scd.2008.0030 ↗
34. 10.1016/j.bbrc.2008.09.15410.1016/j.bbrc.2008.09.154 ↗
35. 10.1016/j.actbio.2011.06.03110.1016/j.actbio.2011.06.031 ↗
36. 10.1016/j.ijbiomac.2021.02.12210.1016/j.ijbiomac.2021.02.122 ↗
37. 10.1002/advs.20190086710.1002/advs.201900867 ↗
38. 10.1016/j.actbio.2017.11.02110.1016/j.actbio.2017.11.021 ↗
39. 10.1016/j.matbio.2007.07.00210.1016/j.matbio.2007.07.002 ↗
40. 10.1016/j.stem.2009.06.01610.1016/j.stem.2009.06.016 ↗
41. 10.1002/art.2213610.1002/art.22136 ↗
42. 10.1039/C9BM01081E10.1039/C9BM01081E ↗
43. 10.1002/jor.2020010.1002/jor.20200 ↗
44. 10.1016/j.actbio.2008.09.02210.1016/j.actbio.2008.09.022 ↗
45. 10.1155/2013/31250110.1155/2013/312501 ↗
46. 10.1016/S0092-8674(00)81867-X10.1016/S0092-8674(00)81867-X ↗
47. Kenneth J. L. · Methods · 2002 · 25 · 402
48. 10.1002/bdrc.2018910.1002/bdrc.20189 ↗
49. 10.1016/j.biomaterials.2013.04.05510.1016/j.biomaterials.2013.04.055 ↗
50. 10.1038/s41413-018-0022-y10.1038/s41413-018-0022-y ↗
51. 10.7554/eLife.2089410.7554/eLife.20894 ↗
52. 10.1098/rsob.18021610.1098/rsob.180216 ↗
53. 10.1038/nrrheum.2016.14810.1038/nrrheum.2016.148 ↗
54. Guilak F. · Biorheology · 2000 · 37 · 27
55. 10.1021/acsami.9b1726610.1021/acsami.9b17266 ↗
56. Horner C. B. · J. Tissue Eng. Regener. Med. · 2016 · 12
57. 10.1038/srep2289810.1038/srep22898 ↗
58. 10.1016/j.actbio.2018.10.01610.1016/j.actbio.2018.10.016 ↗
59. 10.1016/j.actbio.2016.03.01410.1016/j.actbio.2016.03.014 ↗
60. 10.1016/j.biomaterials.2018.01.05710.1016/j.biomaterials.2018.01.057 ↗
61. 10.1152/ajpcell.00415.200510.1152/ajpcell.00415.2005 ↗
62. 10.1159/00037405210.1159/000374052 ↗
63. 10.1073/pnas.100030210710.1073/pnas.1000302107 ↗
64. 10.1089/ten.tea.2015.045710.1089/ten.tea.2015.0457 ↗
65. 10.1016/j.biomaterials.2014.05.05210.1016/j.biomaterials.2014.05.052 ↗
66. 10.22203/eCM.v027a1110.22203/eCM.v027a11 ↗
67. 10.1016/j.eurpolymj.2015.07.02110.1016/j.eurpolymj.2015.07.021 ↗
68. 10.1016/j.biomaterials.2017.05.04510.1016/j.biomaterials.2017.05.045 ↗
69. 10.1021/acsbiomaterials.7b0010110.1021/acsbiomaterials.7b00101 ↗
70. 10.1186/s12861-014-0036-710.1186/s12861-014-0036-7 ↗
71. Mikic B. · J. Rehabil. Res. Dev. · 2000 · 37 · 127
72. 10.1016/S0140-6736(10)60668-X10.1016/S0140-6736(10)60668-X ↗
73. 10.1097/00001665-200111000-0001710.1097/00001665-200111000-00017 ↗
74. Friedenstein A. J. · Cell Tissue Kinet. · 1987 · 20 · 263
75. 10.1016/j.biomaterials.2014.08.02010.1016/j.biomaterials.2014.08.020 ↗
76. 10.1016/j.biomaterials.2013.05.03810.1016/j.biomaterials.2013.05.038 ↗