DataVXAdvanced SciencePaper
journal article·2020-08Open access

Multiscale Analysis of Metal Oxide Nanoparticles in Tissue: Insights into Biodistribution and Biotransformation

Martin T. Matter, Jian‐Hao Li, Ioana Lese, Claudia Schreiner, Laetitia Bernard, Olivier Scholder, Jasmin Hubeli, Kerda Keevend, Elena Tsolaki, Enrico Bertero, Sergio Bertazzo, Robert Zboray, Radu Olariu, Mihai A. Constantinescu, Renato Figi, Inge K. Herrmann

Advanced Science· Volume 7· Issue 15
Publisher pageOpen full text
Source abstract

Abstract

Abstract Metal oxide nanoparticles have emerged as exceptionally potent biomedical sensors and actuators due to their unique physicochemical features. Despite fascinating achievements, the current limited understanding of the molecular interplay between nanoparticles and the surrounding tissue remains a major obstacle in the rationalized development of nanomedicines, which is reflected in their poor clinical approval rate. This work reports on the nanoscopic characterization of inorganic nanoparticles in tissue by the example of complex metal oxide nanoparticle hybrids consisting of crystalline cerium oxide and the biodegradable ceramic bioglass. A validated analytical method based on semiquantitative X‐ray fluorescence and inductively coupled plasma spectrometry is used to assess nanoparticle biodistribution following intravenous and topical application. Then, a correlative multiscale analytical cascade based on a combination of microscopy and spectroscopy techniques shows that the topically applied hybrid nanoparticles remain at the initial site and are preferentially taken up into macrophages, form apatite on their surface, and lead to increased accumulation of lipids in their surroundings. Taken together, this work displays how modern analytical techniques can be harnessed to gain unprecedented insights into the biodistribution and biotransformation of complex inorganic nanoparticles. Such nanoscopic characterization is imperative for the rationalized engineering of safe and efficacious nanoparticle‐based systems.
Source: crossref · Quality: baseline

Research context

Ceramics & glassesNanomaterials

OpenAlex topics: Nanoparticles: synthesis and applications · Nanoparticle-Based Drug Delivery · Bone Tissue Engineering Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Particles‐Biology Interactions, Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Lerchenfeldstrasse 5 St. Gallen 9014 Switzerland

Nanoparticle Systems Engineering Laboratory Institute of Process Engineering Department of Mechanical and Process Engineering ETH Zurich Sonneggstrasse 3 Zurich 8092 Switzerland

Department of Plastic and Hand Surgery University Hospital Bern (Inselspital) University of Bern Bern 3010 Switzerland

Advanced Analytical Technologies Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 Switzerland

Nanoscale Materials Department of Materials Meet Life Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 Switzerland

Department of Medical Physics and Biomedical Engineering University College London (UCL) Malet Place Engineering Building London WC1E 6BT UK

Mechanics of Materials and Nanostructures Swiss Federal Laboratories for Materials Science and Technology (Empa) Feuerwerkerstrasse 39 Thun 3602 Switzerland

Center for X‐ray Analytics Swiss Federal Laboratories for Materials Science and Technology (Empa) Uberlandstrasse 129 Dubendorf 8600 Switzerland

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung · Gottfried und Julia Bangerter-Rhyner-Stiftung · OPO-Stiftung

References (61)

Show source-provided references
1. 10.1073/pnas.050768110210.1073/pnas.0507681102 ↗
2. 10.1016/j.cis.2011.11.00110.1016/j.cis.2011.11.001 ↗
3. 10.1098/rsfs.2013.006510.1098/rsfs.2013.0065 ↗
4. 10.1021/acscentsci.5b0018210.1021/acscentsci.5b00182 ↗
5. 10.1038/nbt.336610.1038/nbt.3366 ↗
6. 10.1007/s12551-016-0246-210.1007/s12551-016-0246-2 ↗
7. 10.1088/0957-4484/17/16/03110.1088/0957-4484/17/16/031 ↗
8. 10.1039/c3cp43938k10.1039/c3cp43938k ↗
9. 10.1002/smll.20090178910.1002/smll.200901789 ↗
10. 10.1016/j.nantod.2014.09.00610.1016/j.nantod.2014.09.006 ↗
11. 10.1038/nature1280610.1038/nature12806 ↗
12. 10.1002/anie.20140104310.1002/anie.201401043 ↗
13. 10.2217/nnm.15.8210.2217/nnm.15.82 ↗
14. 10.1098/rsif.2011.061110.1098/rsif.2011.0611 ↗
15. 10.1039/C7TB01221G10.1039/C7TB01221G ↗
16. 10.1371/journal.pone.020780210.1371/journal.pone.0207802 ↗
17. Ventola C. L. · P T · 2017 · 42 · 742
18. 10.2967/jnumed.116.18136210.2967/jnumed.116.181362 ↗
19. 10.1208/s12248-016-9970-610.1208/s12248-016-9970-6 ↗
20. 10.1007/s11095-016-1958-510.1007/s11095-016-1958-5 ↗
21. 10.1126/science.111439710.1126/science.1114397 ↗
22. 10.1002/anie.20090668410.1002/anie.200906684 ↗
23. 10.1007/978-3-319-47754-1_410.1007/978-3-319-47754-1_4 ↗
24. 10.1371/journal.pone.012636610.1371/journal.pone.0126366 ↗
25. 10.1021/acsami.8b1877810.1021/acsami.8b18778 ↗
26. 10.1039/C8NA00098K10.1039/C8NA00098K ↗
27. 10.1007/s10334-011-0284-510.1007/s10334-011-0284-5 ↗
28. 10.1016/j.ejpb.2015.06.01410.1016/j.ejpb.2015.06.014 ↗
29. 10.1038/srep2993610.1038/srep29936 ↗
30. 10.1016/j.ccr.2018.03.00810.1016/j.ccr.2018.03.008 ↗
31. 10.1038/nmat244210.1038/nmat2442 ↗
32. 10.1021/ie501709s10.1021/ie501709s ↗
33. 10.1039/c3ta01703f10.1039/c3ta01703f ↗
34. 10.1080/0278682090344966510.1080/02786820903449665 ↗
35. 10.1146/annurev-chembioeng-060718-03020310.1146/annurev-chembioeng-060718-030203 ↗
36. 10.1186/s12989-019-0325-110.1186/s12989-019-0325-1 ↗
37. 10.1016/j.aca.2011.08.02410.1016/j.aca.2011.08.024 ↗
38. 10.1038/s41598-017-04098-610.1038/s41598-017-04098-6 ↗
39. 10.1039/C7NR01176H10.1039/C7NR01176H ↗
40. 10.1039/C9EN00222G10.1039/C9EN00222G ↗
41. 10.1093/toxsci/kfq13710.1093/toxsci/kfq137 ↗
42. 10.1002/anie.20120378010.1002/anie.201203780 ↗
43. 10.3390/ijms1901020510.3390/ijms19010205 ↗
44. 10.2217/nnm.11.7910.2217/nnm.11.79 ↗
45. 10.3762/bjnano.6.2510.3762/bjnano.6.25 ↗
46. 10.1016/j.csda.2006.11.00610.1016/j.csda.2006.11.006 ↗
47. 10.1002/jbio.20130013110.1002/jbio.201300131 ↗
48. 10.1073/pnas.141979911210.1073/pnas.1419799112 ↗
49. 10.1016/j.biomaterials.2011.02.03110.1016/j.biomaterials.2011.02.031 ↗
50. 10.1039/C9EN00281B10.1039/C9EN00281B ↗
51. 10.1016/j.biomaterials.2016.01.04710.1016/j.biomaterials.2016.01.047 ↗
52. 10.1038/ncomms479610.1038/ncomms4796 ↗
53. 10.1088/1361-6528/aae36410.1088/1361-6528/aae364 ↗
54. 10.1002/sia.268610.1002/sia.2686 ↗
55. 10.1016/S0731-7085(01)00592-110.1016/S0731-7085(01)00592-1 ↗
56. 10.1145/225545.22554610.1145/225545.225546 ↗
57. 10.1021/acsaem.7b0033410.1021/acsaem.7b00334 ↗
58. 10.1038/nmat362710.1038/nmat3627 ↗
59. 10.1016/j.jallcom.2019.03.27910.1016/j.jallcom.2019.03.279 ↗
60. 10.1038/srep2778910.1038/srep27789 ↗
61. 10.1007/s00216-012-5858-110.1007/s00216-012-5858-1 ↗