DataVXAdvanced SciencePaper
journal article·2024-01Open access

Hydrogel Encapsulating Wormwood Essential Oil with Broad‐spectrum Antibacterial and Immunomodulatory Properties for Infected Diabetic Wound Healing

Feng Wang, Qi Sun, Yang Li, Ruijun Xu, Renjie Li, Dingcai Wu, Rongkang Huang, Zifeng Yang, Yong Li

Advanced Science· Volume 11· Issue 3
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Source abstract

Abstract

Abstract The integration of hydrogels with bio‐friendly functional components through simple and efficient strategies to construct wound dressings with broad‐spectrum antibacterial and immunomodulatory properties to promote the healing of infected diabetic wounds is highly desirable but remains a major challenge. Here, wormwood essential oil (WEO) is effectively encapsulated in the hydrogel via an O/W‐Pickering emulsion during the polymerization of methacrylic anhydride gelatin (GelMA), acrylamide (AM), and acrylic acid N‐hydroxysuccinimide ester (AAc‐NHS) to form a multifunctional hydrogel dressing (HD‐WEO). Compared with conventional emulsions, Pickering emulsions not only improve the encapsulation stability of the WEO, but also enhance the tensile and swelling properties of hydrogel. The synergistic interaction of WEO's diverse bioactive components provides a broad‐spectrum antibacterial activity against S. aureus, E. coli, and MRSA. In addition, the HD‐WEO can induce the polarization of macrophages from M1 to M2 phenotype. With these advantages, the broad‐spectrum antibacterial and immunomodulatory HD‐WEO effectively promotes the collagen deposition and neovascularization, thereby accelerating the healing of MRSA‐infected diabetic wounds.
Source: crossref · Quality: baseline

Research context

PolymersBiomaterialsMaterials processing

OpenAlex topics: Wound Healing and Treatments · Diabetic Foot Ulcer Assessment and Management · Pressure Ulcer Prevention and Management

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China

Department of Gastrointestinal Surgery Department of General Surgery Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University Guangzhou 510080 China

Key Laboratory of Biowaste Resources for Selenium‐Enriched Functional Utilization, College of Petroleum and Chemical Engineering Beibu Gulf University Qinzhou 535011 China

School of Medicine South China University of Technology Guangzhou 510006 China

PCFM Lab School of Chemistry Sun Yat‐sen University Guangzhou 510006 China

The Eighth Affiliated Hospital Sun Yat‐sen University Shenzhen 518033 China

Department of General Surgery (Colorectal Surgery) Guangdong Institute of Gastroenterology Biomedical Innovation Center Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Diseases The Sixth Affiliated Hospital Sun Yat‐sen University Guangzhou 510655 China

Funding

National Key Research and Development Program of China · Natural Science Foundation of Guangxi Province

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