A Versatile Theranostic Platform for Colorectal Cancer Peritoneal Metastases: Real‐Time Tumor‐Tracking and Photothermal‐Enhanced Chemotherapy
Source abstract
Abstract
Abstract A versatile tumor‐targeting stimuli‐responsive theranostic platform for peritoneal metastases of colorectal cancer is proposed in this work for tumor tracking and photothermal‐enhanced chemotherapy. A quenched photosensitizer (“off” state) is developed and escorted into a tumor‐targeting oxaliplatin‐embedded micelle. Once reaching the tumor cell, the micelle is clasped to release free oxaliplatin, as well as the “off” photosensitizer, which is further activated (“turned‐on”) in the tumor reducing microenvironment to provide optical imaging and photothermal effect. The combined results from hyperthermia‐enhanced chemotherapy, deep penetration, perfused O2, and the leveraged GSH‐ROS imbalance in tumor cells are achieved for improved antitumor efficacy and reduced systematic toxicity.
Source: crossref · Quality: baseline
Research context
OpenAlex topics: Nanoplatforms for cancer theranostics · Nanoparticle-Based Drug Delivery · Advanced Photocatalysis Techniques
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
Key Laboratory of Smart Drug Delivery (Ministry of Education) Minhang Hospital State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science Institutes of Brain Science Department of Pharmaceutics School of Pharmacy Fudan University 826 Zhangheng Road Shanghai 201203 China
Shandong Province Key Laboratory of Medical Physics and Image Processing Technology School of Physics and Electronics and Institute of Materials and Clean Energy Shandong Normal University 1 University Road Jinan 250358 P. R. China
References (47)
Show source-provided references
1. 10.1002/jso.2477410.1002/jso.24774 ↗
2. 10.3748/wjg.v25.i27.348410.3748/wjg.v25.i27.3484 ↗
3. 10.1093/annonc/mdw23510.1093/annonc/mdw235 ↗
4. 10.1016/S2468-1253(19)30239-010.1016/S2468-1253(19)30239-0 ↗
5. Mogal H. · J. Gastrointest. Oncol. · 2016 · 7 · 129
6. 10.1080/17425247.2020.173655110.1080/17425247.2020.1736551 ↗
7. 10.1016/j.ejso.2018.10.54210.1016/j.ejso.2018.10.542 ↗
8. 10.1056/NEJMoa170861810.1056/NEJMoa1708618 ↗
9. 10.1016/j.suronc.2010.09.00210.1016/j.suronc.2010.09.002 ↗
10. 10.4155/tde.11.7210.4155/tde.11.72 ↗
11. 10.1002/adma.20140430810.1002/adma.201404308 ↗
12. 10.1002/adma.20190019210.1002/adma.201900192 ↗
13. 10.1016/j.biotechadv.2016.04.00110.1016/j.biotechadv.2016.04.001 ↗
14. 10.1038/nrclinonc.2013.12310.1038/nrclinonc.2013.123 ↗
15. 10.1016/j.jocn.2014.02.00610.1016/j.jocn.2014.02.006 ↗
16. 10.1038/s41563-019-0378-410.1038/s41563-019-0378-4 ↗
17. 10.1039/C6CS00592F10.1039/C6CS00592F ↗
18. 10.1016/j.biomaterials.2018.04.01610.1016/j.biomaterials.2018.04.016 ↗
19. 10.1021/jacs.0c0136510.1021/jacs.0c01365 ↗
20. M. J.Frisch G. W.Trucks H. B.Schlegel G. E.Scuseria M. A.Robb J. R.Cheeseman G.Scalmani V.Barone G. A.Petersson H.Nakatsuji X.Li M.Caricato A. V.Marenich J.Bloino B. G.Janesko R.Gomperts B.Mennucci H. P.Hratchian J. V.Ortiz A. F.Izmaylov J. L.Sonnenberg D.Williams‐Young F.Ding F.Lipparini F.Egidi J.Goings B.Peng A.Petrone T.Henderson D.Ranasinghe V. G.Zakrzewski J.Gao N.Rega G.Zheng W.Liang M.Hada M.Ehara K.Toyota R.Fukuda J.Hasegawa M.Ishida T.Nakajima Y.Honda O.Kitao H.Nakai T.Vreven K.Throssell J. A.MontgomeryJr. J. E.Peralta F.Ogliaro M. J.Bearpark J. J.Heyd E. N.Brothers K. N.Kudin V. N.Staroverov T. A.Keith R.Kobayashi J.Normand K.Raghavachari A. P.Rendell J. C.Burant S. S.Iyengar J.Tomasi M.Cossi J. M.Millam M.Klene C.Adamo R.Cammi J. W.Ochterski R. L.Martin K.Morokuma O.Farkas J. B.Foresman D. J.Fox Gaussian 16 Revision A.03 Gaussian Inc. Wallingford CT2016.
21. 10.1002/jcp.2188510.1002/jcp.21885 ↗
22. 10.1073/pnas.93.18.997010.1073/pnas.93.18.9970 ↗
23. 10.1016/0742-8413(96)00012-610.1016/0742-8413(96)00012-6 ↗
24. Li S. · ACS Nano · 2019 · 13 · 2103
25. 10.1039/D0CC00470G10.1039/D0CC00470G ↗
26. 10.1016/j.biomaterials.2018.02.01110.1016/j.biomaterials.2018.02.011 ↗
27. 10.1021/acsnano.0c0619010.1021/acsnano.0c06190 ↗
28. 10.1039/C9CS00575G10.1039/C9CS00575G ↗
29. 10.1016/j.addr.2010.04.00910.1016/j.addr.2010.04.009 ↗
30. 10.1016/j.abb.2010.05.01410.1016/j.abb.2010.05.014 ↗
31. 10.1016/j.ejso.2013.03.02210.1016/j.ejso.2013.03.022 ↗
32. 10.1002/jso.2010910.1002/jso.20109 ↗
33. 10.1038/nbt107410.1038/nbt1074 ↗
34. 10.1038/s41551-016-001010.1038/s41551-016-0010 ↗
35. 10.1038/nchem.150010.1038/nchem.1500 ↗
36. 10.1038/natrevmats.2017.1410.1038/natrevmats.2017.14 ↗
37. 10.1038/s41551-017-005610.1038/s41551-017-0056 ↗
38. 10.1038/s41592-020-0889-610.1038/s41592-020-0889-6 ↗
39. 10.1002/adfm.20170571010.1002/adfm.201705710 ↗
40. 10.1002/adma.20170358810.1002/adma.201703588 ↗
41. 10.1021/acsnano.7b0721410.1021/acsnano.7b07214 ↗
42. 10.1038/nrc254010.1038/nrc2540 ↗
43. 10.1021/acs.accounts.8b0021410.1021/acs.accounts.8b00214 ↗
44. 10.1021/acs.nanolett.9b0145810.1021/acs.nanolett.9b01458 ↗
45. 10.1016/j.apsb.2020.07.01310.1016/j.apsb.2020.07.013 ↗
46. 10.1016/j.cclet.2018.10.01710.1016/j.cclet.2018.10.017 ↗
47. 10.1016/j.cclet.2018.02.01510.1016/j.cclet.2018.02.015 ↗