Covalent Inhibitors Allosterically Block the Activation of Rho Family Proteins and Suppress Cancer Cell Invasion
Abstract
Research context
OpenAlex topics: Protein Kinase Regulation and GTPase Signaling · Enzyme Structure and Function · Enzyme function and inhibition
SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.
Affiliations
School of Life Science and Technology Harbin Institute of Technology Harbin 150001 China
Drug Discovery and Design Center State Key Laboratory of Drug Research Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China
School of Pharmacy University of Chinese Academy of Sciences Beijing 100049 China
The Second Clinical Medical College, and Guangdong Provincial Key Laboratory of Clinical Research on Traditional Chinese Medicine Syndrome Guangzhou University of Chinese Medicine Guangzhou 510006 China
School of Pharmacy Nanchang University Jiangxi 330006 China
School of Pharmacy Fudan University Shanghai 201203 China
Open Studio for Druggability Research of Marine Natural Products Pilot National Laboratory for Marine Science and Technology (Qingdao) 1 Wenhai Road, Aoshanwei, Jimo Qingdao 266237 China
Guangzhou Key Laboratory of Chirality Research on Active Components of Traditional Chinese Medicine Guangzhou 510006 China
Key Laboratory of Metabolism and Molecular Medicine the Ministry of Education Department of Biochemistry and Molecular Biology School of Basic Medical Sciences Department of Pulmonary and Critical Care Medicine Huashan Hospital Fudan University Shanghai 200032 China
Department of Pharmacology College of Pharmac Fujian Medical University Fuzhou 350004 China
Department of Pharmacy Guizhou University of Traditional Chinese Medicine South Dong Qing Road, Huaxi District Guizhou 550025 China
Funding
National Natural Science Foundation of China · K. C. Wong Education Foundation · Science and Technology Commission of Shanghai Municipality · Chinese Academy of Sciences · Ministry of Science and Technology of the People's Republic of China · National Major Science and Technology Projects of China