DataVXAdvanced SciencePaper
journal article·2020-05Open access

Auger Electrons Constructed Active Sites on Nanocatalysts for Catalytic Internal Radiotherapy

Weiwei Su, Han Wang, Tao Wang, Xiao Li, Zhongmin Tang, Shuai Zhao, Meng Zhang, Danni Li, Xingwu Jiang, Teng Gong, Wei Yang, Changjing Zuo, Yelin Wu, Wenbo Bu

Advanced Science· Volume 7· Issue 10
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Source abstract

Abstract

Abstract Excess electrons play important roles for the construction of superficial active sites on nanocatalysts. However, providing excess electrons to nanocatalysts in vivo is still a challenge, which limits the applications of nanocatalysts in biomedicine. Herein, auger electrons (AEs) emitted from radionuclide 125 (125I) are used in situ to construct active sites in a nanocatalyst (TiO2) and the application of this method is further extended to cancer catalytic internal radiotherapy (CIRT). The obtained 125I‐TiO2 nanoparticles first construct superficial Ti3+ active sites via the reaction between Ti4+ and AEs. Then Ti3+ stretches and weakens the OH bond of the absorbed H2O, thus enhancing the radiolysis of H2O molecules and generating hydroxyl radicals (•OH). All in vitro and in vivo results demonstrate a good CIRT performance. These findings will broaden the application of radionuclides and introduce new perspectives to nanomedicine.
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Research context

NanomaterialsCatalysis & surfaces

OpenAlex topics: Nanoplatforms for cancer theranostics · Advanced Photocatalysis Techniques · Luminescence Properties of Advanced Materials

SciVX discovery tags are terminology-based. OpenAlex topics are source-provided classifications.

Affiliations

Department of Nuclear Medicine Changhai Hospital Naval Medical University Shanghai 200433 P. R. China

University of Chinese Academy of Sciences Beijing 100049 P. R. China

State Key Laboratory of High Performance Ceramics and Superfine Microstructures Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China

Tongji University Cancer Center Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 P. R. China

Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Shanghai 200062 P. R. China

Funding

National Natural Science Foundation of China

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